Reaction Details Report a problem with these data
Target
Histone deacetylase 3
Ligand
BDBM242903
Substrate
n/a
Meas. Tech.
Fluorogenic Inhibition Assay
pH
8.1±n/a
Temperature
310.15±n/a K
IC50
47300±n/a nM
Comments
extracted
Citation
 Gleason, JL; White, JH; Kaldre, D; Fischer, J Bis-(aryl/heteroaryl)-methylene compounds, pharmaceutical compositions containing same and their use for treating cancer US Patent  US9428447 Publication Date 8/30/2016 
Target
Name:
Histone deacetylase 3
Synonyms:
HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45
Type:
Enzyme
Mol. Mass.:
48829.55
Organism:
Homo sapiens (Human)
Description:
O15379
Residue:
428
Sequence:
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI
  
Inhibitor
Name:
BDBM242903
Synonyms:
US9428447, DK-178
Type:
Small organic molecule
Emp. Form.:
C26H39NO4S
Mol. Mass.:
461.657
SMILES:
CCC(CC)(c1cc(C)c(CCC(=O)NO)s1)c1ccc(OCC(O)C(C)(C)C)c(C)c1 |w:23.24|
Structure:
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