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Target
Bromodomain-containing protein 4 [75-147]
Ligand
BDBM223495
Substrate
n/a
Meas. Tech.
Binding Assay
IC50
24.3±n/a nM
Citation
 Bradner, JE; Qi, J Compositions and methods for treating neoplasia, inflammatory disease and other disorders US Patent  US10407441 Publication Date 9/10/2019 
Target
Name:
Bromodomain-containing protein 4 [75-147]
Synonyms:
BRD4 | BRD4_HUMAN | Bromo domain 1 | Bromodomain-containing protein 4 (BD1) | Bromodomain-containing protein 4 (BRD4) Bromo 1 | Bromodomain-containing protein 4 (BRD4)(BD1) | Bromodomain-containing protein 4 (BRD4)(Bromo 1) | Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1) | Bromodomain-containing protein 4 Bromodomain 1 (BRD4-1) | Bromodomain-containing protein 4 Domain 1 | HUNK1
Type:
n/a
Mol. Mass.:
8856.55
Organism:
Homo sapiens (Human)
Description:
BD1 (75-147 aa) of O60885
Residue:
73
Sequence:
WKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIV
  
Inhibitor
Name:
BDBM223495
Synonyms:
US10407441, Compound JQ35 | US9320741, JQ35
Type:
Small organic molecule
Emp. Form.:
C27H34ClN7OS
Mol. Mass.:
540.123
SMILES:
CN1CCN(CCCNC(=O)CC2N=C(c3c(C)c(C)sc3-n3c(C)nnc23)c2ccc(Cl)cc2)CC1 |c:13|
Structure:
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