Reaction Details Report a problem with these data
Target
L-lactate dehydrogenase B chain
Ligand
BDBM436175
Substrate
n/a
Meas. Tech.
Recombinant IDH1 Enzyme Assays
IC50
64070±n/a nM
Citation
 Dang, L; Fantin, V; Gross, S; Jang, HG; Jin, S; Salituro, FG; Saunders, JO; Su, SM; Yen, K Methods and compositions for cell-proliferation-related disorders US Patent  US10610125 Publication Date 4/7/2020 
Target
Name:
L-lactate dehydrogenase B chain
Synonyms:
L-lactate dehydrogenase B | L-lactate dehydrogenase B chain | LDH heart subunit | LDH-B | LDH-H | LDHB | LDHB_HUMAN | Lactate dehydrogenase B (LDHB) | Renal carcinoma antigen NY-REN-46
Type:
Oxidoreductase; homotetramer
Mol. Mass.:
36635.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
334
Sequence:
MATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARGLTSVINQKLKDDEVAQLKKSADTLWDIQKDLKDL
  
Inhibitor
Name:
BDBM436175
Synonyms:
US10610125, Example Table 24a.1
Type:
Small organic molecule
Emp. Form.:
C22H13N3O2S
Mol. Mass.:
383.423
SMILES:
Cc1c(\C=C2/Sc3ccccc3C2=O)c(O)n2c3ccccc3nc2c1C#N
Structure:
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