Reaction Details Report a problem with these data
Target
Estrogen receptor [Y537S]
Ligand
BDBM443439
Substrate
n/a
Meas. Tech.
Competition Binding Assay
Ki
15.8±n/a nM
Citation
 Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ Selective estrogen receptor degraders US Patent  US10654866 Publication Date 5/19/2020 
Target
Name:
Estrogen receptor [Y537S]
Synonyms:
ESR | ESR1 | ESR1_HUMAN | Estrogen receptor (Y537S) | Estrogen receptor alpha Y537S | NR3A1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
66154.35
Organism:
Homo sapiens (Human)
Description:
P03372[Y537S]
Residue:
595
Sequence:
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
  
Inhibitor
Name:
BDBM443439
Synonyms:
US10654866, Example 6 | US11117902, Example 6 | US11634426, Example 6
Type:
Small organic molecule
Emp. Form.:
C28H24F2N2O3
Mol. Mass.:
474.4986
SMILES:
Oc1ccc2c3C(Oc4c(F)cccc4-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1
Structure:
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