Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM443477
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
<1000±n/a nM
Citation
 Wiles, JA; Phadke, AS; Deshpande, M; Agarwal, A; Chen, D; Gadhachanda, VR; Hashimoto, A; Pais, G; Wang, Q; Wang, X Amino compounds for treatment of medical disorders US Patent  US10660876 Publication Date 5/26/2020 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM443477
Synonyms:
(2S,4R)-1-(2-(3- acetyl-5- (pyrimidin-5- ylamino)-1H- indol-1-yl)acetyl)- 4-fluoro-N-(4- hydroxypyridin-2- yl)pyrrolidine-2- carboxamide | US10660876, Cmpd No. 72
Type:
Small organic molecule
Emp. Form.:
C26H24FN7O4
Mol. Mass.:
517.5117
SMILES:
CC(=O)c1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cc(O)ccn2)c2ccc(Nc3cncnc3)cc12 |r|
Structure:
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