Reaction Details Report a problem with these data
Target
Plasminogen [101-181]
Ligand
BDBM290272
Substrate
n/a
Meas. Tech.
Plasma-Based Clot Lysis Assay
IC50
31.0±n/a nM
Citation
 Haßfeld, J; Kinzel, T; Köbberling, J; Cancho-Grande, Y; Beyer, K; Röhrig, S; Köllnberger, M; Sperzel, M; Burkhardt, N; Schlemmer, K; Stegmann, C; Schuhmacher, J; Werner, M; Ellermann, M (Aza)pyridopyrazolopyrimidinones and indazolopyrimidinones and their use US Patent  US10668071 Publication Date 6/2/2020 
Target
Name:
Plasminogen [101-181]
Synonyms:
PLG | PLMN_HUMAN | Plasminogen (aa 101-181)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
9281.08
Organism:
Homo sapiens (Human)
Description:
P00747[101-181]
Residue:
81
Sequence:
SECKTGNGKNYRGTMSKTKNGITCQKWSSTSPHRPRFSPATHPSEGLEENYCRNPDNDPQGPWCYTTDPEKRYDYCDILEC
  
Inhibitor
Name:
BDBM290272
Synonyms:
8-tert-Butyl-4-(piperidin-4-yl)pyrido[2′,3′:3,4]pyrazolo[1,5-a]pyrimidin-2(1H)-one hydrochloride | US10098883, Example 13 | US10668071, Example 13
Type:
Small organic molecule
Emp. Form.:
C18H23N5O
Mol. Mass.:
325.4081
SMILES:
CC(C)(C)c1ccc2c(nn3c(cc(=O)[nH]c23)C2CCNCC2)n1
Structure:
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