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Target
Isocitrate dehydrogenase [NADP] cytoplasmic
Ligand
BDBM445392
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
<100±n/a nM
Citation
 Jiang, L; Geng, M; Zheng, Q; Huang, M; Wan, H; Tang, S; Fu, X; Lan, X; Cao, J; Liu, F; Ding, J Compound having mutant IDH inhibitory activity, preparation method and use thereof US Patent  US10682352 Publication Date 6/16/2020 
Target
Name:
Isocitrate dehydrogenase [NADP] cytoplasmic
Synonyms:
Cytosolic NADP-isocitrate dehydrogenase | IDH | IDH1 | IDHC_HUMAN | IDP | Isocitrate Dehydrogenase (IDH1) | Isocitrate dehydrogenase 1 (IDH1) | NADP(+)-specific ICDH | Oxalosuccinate decarboxylase | PICD
Type:
Protein
Mol. Mass.:
46661.29
Organism:
Homo sapiens (Human)
Description:
O75874
Residue:
414
Sequence:
MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL
  
Inhibitor
Name:
BDBM445392
Synonyms:
(S)-8-isopropyl-7-(2-(((S)-1-(1-(4-trifluoromethylphenyl)-1H-imidazol-4-yl)ethyl)amino)pyrimidin-4-yl)-2-oxa-5,7-diazaspiro[3.4]oct-6-one | US10682352, Compound 105
Type:
Small organic molecule
Emp. Form.:
C24H26F3N7O2
Mol. Mass.:
501.5041
SMILES:
CC(C)[C@@H]1N(C(=O)NC11COC1)c1ccnc(N[C@@H](C)c2cn(cn2)-c2ccc(cc2)C(F)(F)F)n1 |r|
Structure:
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