192 articles for thisTarget
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Bioactive diterpenoids from Trigonostemon chinensis: Structures, NO inhibitory activities, and interactions with iNOS.
Nankai University
Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
Northwestern University
Design, synthesis and biological evaluation of bivalent benzoxazolone and benzothiazolone ligands as potential anti-inflammatory/analgesic agents.
Beni-Suef University
New Monocyclic, Bicyclic, and Tricyclic Ethynylcyanodienones as Activators of the Keap1/Nrf2/ARE Pathway and Inhibitors of Inducible Nitric Oxide Synthase.
Stony Brook University
Selective Acetamidine-Based Nitric Oxide Synthase Inhibitors: Synthesis, Docking, and Biological Studies.
University of Chieti&Quot;G. D'Annunzio&Quot
2-Aminopyridines with a Truncated Side Chain To Improve Human Neuronal Nitric Oxide Synthase Inhibitory Potency and Selectivity.
Northwestern University
Synthesis and biological evaluation of novel pyrazoline derivatives as potent anti-inflammatory agents.
Sichuan University
Structural exploration, synthesis and pharmacological evaluation of novel 5-benzylidenethiazolidine-2,4-dione derivatives as iNOS inhibitors against inflammatory diseases.
Sichuan University
Novel 2,4-disubstituted pyrimidines as potent, selective, and cell-permeable inhibitors of neuronal nitric oxide synthase.
Northwestern University
Structure-based design of bacterial nitric oxide synthase inhibitors.
University of California
Combination of chiral linkers with thiophenecarboximidamide heads to improve the selectivity of inhibitors of neuronal nitric oxide synthase.
Northwestern University
Nitric oxide synthase inhibitors that interact with both heme propionate and tetrahydrobiopterin show high isoform selectivity.
Northwestern University
Simplified 2-aminoquinoline-based scaffold for potent and selective neuronal nitric oxide synthase inhibition.
Northwestern University
Potent and selective double-headed thiophene-2-carboximidamide inhibitors of neuronal nitric oxide synthase for the treatment of melanoma.
Northwestern University
Octulosonic acid derivatives from Roman chamomile (Chamaemelum nobile) with activities against inflammation and metabolic disorder.
University of Mississippi
An Accessible Chiral Linker to Enhance Potency and Selectivity of Neuronal Nitric Oxide Synthase Inhibitors.
Northwestern University
Chemopreventive and antioxidant activity of 6-substituted imidazo[2,1-b]thiazoles.
Universit£
Chiral linkers to improve selectivity of double-headed neuronal nitric oxide synthase inhibitors.
Northwestern University
In search of potent and selective inhibitors of neuronal nitric oxide synthase with more simple structures.
Northwestern University
Investigations on synthesis and structure elucidation of novel [1,2,4]triazolo[1,2-a]pyridazine-1-thiones and their inhibitory activity against inducible nitric oxide synthase.
Ernst-Moritz-Arndt University Greifswald
Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida.
The University of Mississippi
Target- and mechanism-based therapeutics for neurodegenerative diseases: strength in numbers.
Northwestern University
Cyclopropyl- and methyl-containing inhibitors of neuronal nitric oxide synthase.
University of California
Anti-inflammatory lanostanoids and lactone derivatives from Antrodia camphorata.
National Sun Yat-Sen University
Structure-guided design of selective inhibitors of neuronal nitric oxide synthase.
Northwestern University
Novel nanomolar imidazo[4,5-b]pyridines as selective nitric oxide synthase (iNOS) inhibitors: SAR and structural insights.
Nycomed
Optimization of thiazole analogues of resveratrol for induction of NAD(P)H:quinone reductase 1 (QR1).
Purdue University
Discovery of a potent, orally bioavailable and highly selective human neuronal nitric oxide synthase (nNOS) inhibitor, N-(1-(piperidin-4-yl)indolin-5-yl)thiophene-2-carboximidamide as a pre-clinical development candidate for the treatment of migraine.
Neuraxon
1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors: lead optimization studies resulting in the identification of N-(1-(2-(methylamino)ethyl)-1,2,3,4-tetrahydroquinolin-6-yl)thiophene-2-carboximidamide as a preclinical development candidate.
Neuraxon
Synthesis, biological evaluation and molecular docking studies of 3-(triazolyl)-coumarin derivatives: effect on inducible nitric oxide synthase.
Universidade De S£O Paulo
Saquayamycins G-K, cytotoxic angucyclines from Streptomyces sp. Including two analogues bearing the aminosugar rednose.
University of Kentucky
NOpiates: Novel Dual Action Neuronal Nitric Oxide Synthase Inhibitors with µ-Opioid Agonist Activity.
TBA
New synthesis and promising neuroprotective role in experimental ischemic stroke of ONO-1714.
Instituto Cajal (Csic)
Rational design, synthesis, and pharmacological properties of pyranochalcone derivatives as potent anti-inflammatory agents.
Sichuan University
First-in-class, dual-action, 3,5-disubstituted indole derivatives having human nitric oxide synthase (nNOS) and norepinephrine reuptake inhibitory (NERI) activity for the treatment of neuropathic pain.
Neuraxon
Novel, druglike 1,7-disubstituted 2,3,4,5-tetrahydro-1H-benzo[b]azepine-based selective inhibitors of human neuronal nitric oxide synthase (nNOS).
Neuraxon
Oroxylin A analogs exhibited strong inhibitory activities against iNOS-mediated nitric oxide (NO) production.
Kangwon National University
Discovery of N-(3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) thiophene-2-carboximidamide as a selective inhibitor of human neuronal nitric oxide synthase (nNOS) for the treatment of pain.
Neuraxon
Biologically active constituents from the fruiting body of Taiwanofungus camphoratus.
National Formosa University
Synthesis and evaluation of pyrido[1,2-a]pyrimidines as inhibitors of nitric oxide synthases.
Christian-Albrechts-University of Kiel
New diterpenoids and the bioactivity of Erythrophleum fordii.
National Cheng Kung University
Design and synthesis of 7-alkoxy-4-heteroarylamino-3-quinolinecarbonitriles as dual inhibitors of c-Src kinase and nitric oxide synthase.
China Pharmaceutical University
"Virtual fragment linking": an approach to identify potent binders from low affinity fragment hits.
Novartis Institutes For Biomedical Research
N(delta)-Methylated L-arginine derivatives and their effects on the nitric oxide generating system.
Christian-Albrechts-University of Kiel
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
University of Oxford
Design, synthesis, and preliminary evaluation of 4-(6-(3-nitroguanidino)hexanamido)pyrrolidine derivatives as potential iNOS inhibitors.
Shandong University
N(G)-aminoguanidines from primary amines and the preparation of nitric oxide synthase inhibitors.
University of California
Novel 2-aminobenzothiazoles as selective neuronal nitric oxide synthase inhibitors.
Neuraxon
Studies on the reactivity of CDDO, a promising new chemopreventive and chemotherapeutic agent: implications for a molecular mechanism of action.
Dartmouth College
L-arginine analogs as alternate substrates for nitric oxide synthase.
University of California
Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase.
Merck Research Laboratory
5-Fluorinated L-lysine analogues as selective induced nitric oxide synthase inhibitors.
Pfizer
Potent and selective conformationally restricted neuronal nitric oxide synthase inhibitors.
Northwestern University
Aromatic reduced amide bond peptidomimetics as selective inhibitors of neuronal nitric oxide synthase.
Northwestern University
1,2-Dihydro-4-quinazolinamines: potent, highly selective inhibitors of inducible nitric oxide synthase which show antiinflammatory activity in vivo.
Astrazeneca R&D Charnwood
Computer modeling of selective regions in the active site of nitric oxide synthases: implication for the design of isoform-selective inhibitors.
Northwestern University
Synthesis and biological characterization of L-N(6)-(1-iminoethyl)lysine 5-tetrazole-amide, a prodrug of a selective iNOS inhibitor.
Pfizer
Inhibition of protein-protein association by small molecules: approaches and progress.
Pfizer
Reduced amide bond peptidomimetics. (4S)-N-(4-amino-5-[aminoakyl]aminopentyl)-N'-nitroguanidines, potent and highly selective inhibitors of neuronal nitric oxide synthase.
Northwestern University
Synthesis and evaluation of peptidomimetics as selective inhibitors and active site probes of nitric oxide synthases.
Northwestern University
N(omega)-Nitroarginine-containing dipeptide amides. Potent and highly selective inhibitors of neuronal nitric oxide synthase.
Northwestern University
2-Iminohomopiperidinium salts as selective inhibitors of inducible nitric oxide synthase (iNOS).
Pfizer
2-Iminopyrrolidines as potent and selective inhibitors of human inducible nitric oxide synthase.
Pfizer
N-Phenylamidines as selective inhibitors of human neuronal nitric oxide synthase: structure-activity studies and demonstration of in vivo activity.
Glaxo Wellcome Research and Development
Potent and selective inhibition of neuronal nitric oxide synthase by N omega-propyl-L-arginine.
Northwestern University
Selective inhibition of neuronal nitric oxide synthase by N omega-nitroarginine-and phenylalanine-containing dipeptides and dipeptide esters.
Northwestern University
Substituted N-phenylisothioureas: potent inhibitors of human nitric oxide synthase with neuronal isoform selectivity.
Glaxo Wellcome Research and Development
2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms.
G. D. Searle Research and Development
L-N6-(1-iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase.
G. D. Searle Research and Development
Dihydroquinolines with amine-containing side chains as potent n-NOS inhibitors.
Schering
Inhibition of inducible nitric oxide synthase by acetamidine derivatives of hetero-substituted lysine and homolysine.
Glaxo Wellcome Research and Development
1H-pyrazole-1-carboxamidines: new inhibitors of nitric oxide synthase.
Northwestern University
Optimization of the aromatase inhibitory activities of pyridylthiazole analogues of resveratrol.
Purdue University
Intramolecular hydrogen bonding: a potential strategy for more bioavailable inhibitors of neuronal nitric oxide synthase.
Northwestern University
3,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase (nNOS) inhibitors.
Neuraxon
Discovery of cis-N-(1-(4-(methylamino)cyclohexyl)indolin-6-yl)thiophene-2-carboximidamide: a 1,6-disubstituted indoline derivative as a highly selective inhibitor of human neuronal nitric oxide synthase (nNOS) without any cardiovascular liabilities.
Neuraxon
1,3,4-Thiadiazole derivatives as selective inhibitors of iNOS versus nNOS: Synthesis and structure-activity dependence.
Universidad De Granada
Secondary metabolites from the roots of Neolitsea daibuensis and their anti-inflammatory activity.
Kaohsiung Medical University
Bis-chalcone analogues as potent NO production inhibitors and as cytotoxic agents.
National Cheng Kung University
Design, synthesis, and biological evaluation of 3,4-dihydroquinolin-2(1H)-one and 1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors.
Neuraxon
Design, synthesis, and biological evaluation of callophycin A and analogues as potential chemopreventive and anticancer agents.
University of Hawaii At Hilo
Identification and SAR of selective inducible nitric oxide synthase (iNOS) dimerization inhibitors.
Kalypsys
Anti-inflammatory endiandric acid analogues from the roots of Beilschmiedia tsangii.
Kaohsiung Medical University
1,6-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors.
Neuraxon
1,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors.
Neuraxon
Improved synthesis of chiral pyrrolidine inhibitors and their binding properties to neuronal nitric oxide synthase.
Northwestern University
Oxadiazole derivatives containing 1,4-benzodioxan as potential immunosuppressive agents against RAW264.7 cells.
Nanjing University
Discovery of dual inducible/neuronal nitric oxide synthase (iNOS/nNOS) inhibitor development candidate 4-((2-cyclobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one (KD7332) part 2: identification of a novel, potent, and selective series of benzimidazole-quinolinone iNOS/nNO
Kalypsys
Heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase; the identification of (2R)-2-pyrrolidinecarboxamidine as a potent and selective haem-co-ordinating inhibitor.
Glaxosmithkline
Symmetric double-headed aminopyridines, a novel strategy for potent and membrane-permeable inhibitors of neuronal nitric oxide synthase.
Northwestern University
Synthesis and biological evaluation of novel 5-benzylidenethiazolidine-2,4-dione derivatives for the treatment of inflammatory diseases.
Sichuan University
The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS).
Astrazeneca Charnwood
Exploration of the active site of neuronal nitric oxide synthase by the design and synthesis of pyrrolidinomethyl 2-aminopyridine derivatives.
Northwestern University
N-Substituted acetamidines and 2-methylimidazole derivatives as selective inhibitors of neuronal nitric oxide synthase.
Università
Peripheral but crucial: a hydrophobic pocket (Tyr(706), Leu(337), and Met(336)) for potent and selective inhibition of neuronal nitric oxide synthase.
Northwestern University
Structure-based design, synthesis, and biological evaluation of lipophilic-tailed monocationic inhibitors of neuronal nitric oxide synthase.
Northwestern University
Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites.
Purdue University
2-aminoimidazole amino acids as inhibitors of the binuclear manganese metalloenzyme human arginase I.
University of Pennsylvania
Potent and selective neuronal nitric oxide synthase inhibitors with improved cellular permeability.
Northwestern University
Fluorinated indazoles as novel selective inhibitors of nitric oxide synthase (NOS): synthesis and biological evaluation.
Uned
Synthesis, biological evaluation, and docking studies of N-substituted acetamidines as selective inhibitors of inducible nitric oxide synthase.
Universita G. D'Annunzio
1,2-diaminobenzimidazoles : Selective inhibitors of nitric oxide synthase derived from aminoguanidine
TBA
Design and synthesis of 2-amino-4-methylpyridine analogues as inhibitors for inducible nitric oxide synthase and in vivo evaluation of [18F]6-(2-fluoropropyl)-4-methyl-pyridin-2-amine as a potential PET tracer for inducible nitric oxide synthase.
Washington University
Analogues of 2-aminopyridine-based selective inhibitors of neuronal nitric oxide synthase with increased bioavailability.
Northwestern University
4,4-Difluorinated analogues of l-arginine and N(G)-hydroxy-l-arginine as mechanistic probes for nitric oxide synthase.
University of Utrecht
Discovery of highly potent and selective inhibitors of neuronal nitric oxide synthase by fragment hopping.
Northwestern University
Synthesis of biflavones having a 6-O-7'' linkage and effects on cyclooxygenase-2 and inducible nitric oxide synthase.
Kangwon National University
The design, synthesis and biological evaluation of 7-alkoxy-4-heteroarylamino-3-cyanoquinolines as dual inhibitors of c-Src and iNOS.
China Pharmaceutical University
Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: particular potency of 1H-indazole-7-carbonitrile.
Université
New crinine-type alkaloids with inhibitory effect on induction of inducible nitric oxide synthase from Crinum yemense.
Mansoura University
1-(1,3-Benzodioxol-5-ylmethyl)-3-[4-(1H-imidazol-1-yl)phenoxy]-piperidine analogs as potent and selective inhibitors of nitric oxide formation.
Berlex Biosciences
The rational design of inhibitors of nitric oxide formation by inducible nitric oxide synthase.
Berlex Biosciences
Design, synthesis, and activity of 2-imidazol-1-ylpyrimidine derived inducible nitric oxide synthase dimerization inhibitors.
Berlex Biosciences
Selective L-nitroargininylaminopyrrolidine and L-nitroargininylaminopiperidine neuronal nitric oxide synthase inhibitors.
Northwestern University
Conformationally restricted dipeptide amides as potent and selective neuronal nitric oxide synthase inhibitors.
Northwestern University
Structural analysis of isoform-specific inhibitors targeting the tetrahydrobiopterin binding site of human nitric oxide synthases.
Sanofi-Aventis
Evaluation of 3-substituted arginine analogs as selective inhibitors of human nitric oxide synthase isozymes.
Nagoya City University
2-Aminopyridines with a shortened amino sidechain as potent, selective, and highly permeable human neuronal nitric oxide synthase inhibitors.
Northwestern University
Bicyclic amidine inhibitors of nitric oxide synthase: discovery of perhydro-iminopyrindine and perhydro-iminoquinoline as potent, orally active inhibitors of inducible nitric oxide synthase.
Merck Research Laboratories
Novel and orally bioavailable inducible nitric oxide synthase inhibitors: synthesis and evaluation of optically active 4,5-dialkyl-2-iminoselenazolidine derivatives.
Dainippon Pharmaceutical
Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases.
Merck Research Laboratories
2-aminopyridines as highly selective inducible nitric oxide synthase inhibitors. Differential binding modes dependent on nitrogen substitution.
Astrazeneca R&D Charnwood
Structure-activity relationships of potent, selective inhibitors of neuronal nitric oxide synthase based on the 6-phenyl-2-aminopyridine structure.
Pfizer
4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: a new class of orally bioavailable nitric oxide synthase inhibitor.
Dainippon Pharmaceutical
Discovery and development of novel pyrimidine and pyrazolo/thieno-fused pyrimidine derivatives as potent and orally active inducible nitric oxide synthase dimerization inhibitor with efficacy for arthritis.
Anhui Medical University
Synthesis, bioevaluation and docking studies of new imidamide derivatives as nitric oxide synthase inhibitors.
Universidad De Granada
3-Hydroxy-4-methyl-5-pentyl-2-iminopyrrolidine: a potent and highly selective inducible nitric oxide synthase inhibitor.
Pharmacia
Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. Part 1: synthesis and biological evaluation of dihydropyridin-2-imines.
Fukui Research Institute
The synthesis and effect of fluorinated chalcone derivatives on nitric oxide production.
Universidad De Valencia
Design and synthesis of new disubstituted benzoxazolone derivatives that act as iNOS inhibitors with potent anti-inflammatory activity against LPS-induced acute lung injury (ALI).
Shanxi Medical University
Ocular Disease Therapeutics: Design and Delivery of Drugs for Diseases of the Eye.
Taipei Medical University
Selective heterocyclic amidine inhibitors of human inducible nitric oxide synthase.
Pharmacia
Antiglioma Activity of Aryl and Amido-Aryl Acetamidine Derivatives Targeting iNOS: Synthesis and Biological Evaluation.
University "G. D'Annunzio" of Chieti-Pescara
Thienopyridines: nitric oxide synthase inhibitors with potent in vivo activity.
Astrazeneca R&D Charnwood
3,4-Dihydro-1-isoquinolinamines: a novel class of nitric oxide synthase inhibitors with a range of isoform selectivity and potency.
Astrazeneca R&D Charnwood
Evaluation of new L-thiocitrulline derivatives as inhibitors of nitric oxide synthase.
Wake Forest University
Substituted 2-aminopyridines as inhibitors of nitric oxide synthases.
Merck Research Laboratories
Examination of N-hydroxylation as a prerequisite mechanism of nitric oxide synthase inactivation.
University At Buffalo
Human disorders associated with inflammation and the evolving role of natural products to overcome.
University of Delhi
Guanidine-substituted imidazoles as inhibitors of nitric oxide synthase.
Wake Forest University Winston-Salem
Optimization of Blood-Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2-Aminopyridine Scaffold.
Northwestern University
Synthesis and evaluation of new sulfur-containing L-arginine-derived inhibitors of nitric oxide synthase.
Wake Forest University
Conformationally constrained NO synthase inhibitors: rigid analogs of L-N-iminoethylornithine.
Université
Synthesis of boronic acid analogs of L-arginine as alternate substrates or inhibitors of nitric oxide synthase.
Université
Novel Pyrazolo[4,3- d]pyrimidine as Potent and Orally Active Inducible Nitric Oxide Synthase (iNOS) Dimerization Inhibitor with Efficacy in Rheumatoid Arthritis Mouse Model.
Anhui Medical University
First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate.
Northwestern University
Nitroaromatic amino acids as inhibitors of neuronal nitric oxide synthase.
Abbott Laboratories
Acetamidine lysine derivative, N-(5(S)-amino-6,7-dihydroxyheptyl)ethanimidamide dihydrochloride: a highly selective inhibitor of human inducible nitric oxide synthase.
Searle
Substituted 2-iminopiperidines as inhibitors of human nitric oxide synthase isoforms.
G. D. Searle Research and Development
Synthesis and evaluation of two positron-labeled nitric oxide synthase inhibitors, S-[11C]methylisothiourea and S-(2-[18F]fluoroethyl)isothiourea, as potential positron emission tomography tracers.
Washington University
Phenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase.
Northwestern University
Discovery and optimization of 1,3,5-trisubstituted pyrazolines as potent and highly selective allosteric inhibitors of protein kinase C-?.
Saarland University
Plakolide A, a new gamma-lactone from the marine sponge Plakortis sp.
Harbor Branch Oceanographic Institution
Synthesis and biological evaluation of clovamide analogues as potent anti-neuroinflammatory agents in vitro and in vivo.
China Pharmaceutical University
Success stories of natural product-based hybrid molecules for multi-factorial diseases.
Punjabi University
Discovery of N-{3-[(ethanimidoylamino)methyl]benzyl}-l-prolinamide dihydrochloride: A new potent and selective inhibitor of the inducible nitric oxide synthase as a promising agent for the therapy of malignant glioma.
University of Chieti "G. D'Annunzio
Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors.
Northwestern University
Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors.
Northwestern University
Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker.
Northwestern University
2-(2-indolyl-)-4(3H)-quinazolines derivates as new inhibitors of AChE: design, synthesis, biological evaluation and molecular modelling.
Sun Yat-Sen University
Affinity map of bromodomain protein 4 (BRD4) interactions with the histone H4 tail and the small molecule inhibitor JQ1.
Bayer Healthcare
Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology.
Case Western Reserve University
Coupling of metabotropic glutamate receptors 2 and 4 to G alpha 15, G alpha 16, and chimeric G alpha q/i proteins: characterization of new antagonists.
Upr Centre
Pharmacologic characterization of CI-996, a new angiotensin receptor antagonist.
Parke-Davis Pharmaceutical Research
Alkyl-CoA disulfides as inhibitors and mechanistic probes for FabH enzymes.
Portland State University
Covalent reactions of wortmannin under physiological conditions.
Massachusetts General Hospital
Discovery of antibacterial biotin carboxylase inhibitors by virtual screening and fragment-based approaches.
Pfizer