110 articles for thisTarget
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Development of 1,2,4-Oxadiazoles as Potent and Selective Inhibitors of the Human Deacetylase Sirtuin 2: Structure-Activity Relationship, X-ray Crystal Structure, and Anticancer Activity.
University of Bayreuth
Identification of the Binding Site of Chroman-4-one-Based Sirtuin 2-Selective Inhibitors using Photoaffinity Labeling in Combination with Tandem Mass Spectrometry.
University of Gothenburg
Cyclic peptide-based potent and selective SIRT1/2 dual inhibitors harboring N
Jiangsu University
Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity.
University of Paris
How much successful are the medicinal chemists in modulation of SIRT1: A critical review.
Guru Jambheshwar University of Science and Technology
Simple N(e)-thioacetyl-lysine-containing cyclic peptides exhibiting highly potent sirtuin inhibition.
Jiangsu University
Aminothiazoles as Potent and Selective Sirt2 Inhibitors: A Structure-Activity Relationship Study.
Albert-Ludwigs-University of Freiburg
Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics.
University of Genoa
Design and Evaluation of 3-(Benzylthio)benzamide Derivatives as Potent and Selective SIRT2 Inhibitors.
Northwestern University
Discovery of bicyclic pyrazoles as class III histone deacetylase SIRT1 and SIRT2 inhibitors.
Methylgene
Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells.
Istituto Ortopedico Rizzoli (Ior)
Functionalized tetrahydro-1H-pyrido[4,3-b]indoles: a novel chemotype with Sirtuin 2 inhibitory activity.
National University of Singapore
Design, synthesis and structure-activity relationship studies of novel sirtuin 2 (SIRT2) inhibitors with a benzamide skeleton.
The University of Tokyo
Chroman-4-one- and chromone-based sirtuin 2 inhibitors with antiproliferative properties in cancer cells.
University of Gothenburg
Discovery of potent and selective sirtuin 2 (SIRT2) inhibitors using a fragment-based approach.
University of Minnesota
Benzimidazoles as new scaffold of sirtuin inhibitors: green synthesis, in vitro studies, molecular docking analysis and evaluation of their anti-cancer properties.
Universiti Sains Malaysia
Development and characterization of 3-(benzylsulfonamido)benzamides as potent and selective SIRT2 inhibitors.
Northwestern University
Development of pyrazolone and isoxazol-5-one cambinol analogues as sirtuin inhibitors.
Fred Hutchinson Cancer Research Center
Identification of novel SIRT2-selective inhibitors using a click chemistry approach.
Nagoya City University
Synthesis and evaluation of novel benzimidazole derivatives as sirtuin inhibitors with antitumor activities.
Universiti Sains Malaysia
Screen of pseudopeptidic inhibitors of human sirtuins 1-3: two lead compounds with antiproliferative effects in cancer cells.
University of Eastern Finland
Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3.
Sirtris A Gsk
Discovery and mechanism study of SIRT1 activators that promote the deacetylation of fluorophore-labeled substrate.
Chinese Academy of Sciences
Creation of an HDAC-based yeast screening method for evaluation of marine-derived actinomycetes: discovery of streptosetin A.
San Francisco State University
Discovery of salermide-related sirtuin inhibitors: binding mode studies and antiproliferative effects in cancer cells including cancer stem cells.
Sapienza University of Rome
Ethylenediamine diacetate (EDDA) mediated synthesis of aurones under ultrasound: their evaluation as inhibitors of SIRT1.
University of Hyderabad Campus
Benzodeazaoxaflavins as sirtuin inhibitors with antiproliferative properties in cancer stem cells.
Sapienza University of Rome
SIRT1 modulation as a novel approach to the treatment of diseases of aging.
Sirtris A Gsk
Synthesis and evaluation of substituted chroman-4-one and chromone derivatives as sirtuin 2-selective inhibitors.
University of Gothenburg
Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors.
Kyoto Prefectural University of Medicine
Novel 3-arylideneindolin-2-ones as inhibitors of NAD+ -dependent histone deacetylases (sirtuins).
Ludwig-Maximilians-Universit£T M£Nchen
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.
Sirtris Pharmaceuticals
Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode.
Albert-Ludwigs-University of Freiburg
N-(3-(4-Hydroxyphenyl)-propenoyl)-amino acid tryptamides as SIRT2 inhibitors.
University of Kuopio
N,N'-Bisbenzylidenebenzene-1,4-diamines and N,N'-Bisbenzylidenenaphthalene-1,4-diamines as Sirtuin Type 2 (SIRT2) Inhibitors.
University of Kuopio
Synthesis and biological characterisation of sirtuin inhibitors based on the tenovins.
University of St. Andrews
Structure-based design of pseudopeptidic inhibitors for SIRT1 and SIRT2.
University of Eastern Finland
A mechanism-based potent sirtuin inhibitor containing Ne-thiocarbamoyl-lysine (TuAcK).
University of Akron
Computer- and structure-based lead design for epigenetic targets.
Martin-Luther University of Halle-Wittenberg
Synthesis and biological activity of splitomicin analogs targeted at human NAD(+)-dependent histone deacetylases (sirtuins).
Ernst-Moritz-Arndt University Greifswald
After the grape rush: sirtuins as epigenetic drug targets in neurodegenerative disorders.
Cemm-Research Center For Molecular Medicine of The Austrian Academy of Sciences
Simplification of the tetracyclic SIRT1-selective inhibitor MC2141: coumarin- and pyrimidine-based SIRT1/2 inhibitors with different selectivity profile.
Sapienza University of Rome
Two-step synthesis of novel, bioactive derivatives of the ubiquitous cofactor nicotinamide adenine dinucleotide (NAD).
University of East Anglia
N(epsilon)-Modified lysine containing inhibitors for SIRT1 and SIRT2.
University of Eastern Finland
Chemical probes for histone-modifying enzymes.
Johns Hopkins University School of Medicine
Characterization of sirtuin inhibitors in nematodes expressing a muscular dystrophy protein reveals muscle cell and behavioral protection by specific sirtinol analogues.
Institute of Psychiatry and Neuroscience of Paris
Identification of a cell-active non-peptide sirtuin inhibitor containing N-thioacetyl lysine.
Nagoya City University
N(epsilon)-thioacetyl-lysine-containing tri-, tetra-, and pentapeptides as SIRT1 and SIRT2 inhibitors.
University of Kuopio
Characterization of the binding properties of SIRT2 inhibitors with a N-(3-phenylpropenoyl)-glycine tryptamide backbone.
University of Kuopio
Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease.
Harvard Medical School
Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition.
Albert-Ludwigs-University of Freiburg
Discovering inhibitors of human sirtuin type 2: novel structural scaffolds.
University of Kuopio
Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1.
Elixir Pharmaceuticals
Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors.
Sapienza University of Rome
Therapeutic Potential and Activity Modulation of the Protein Lysine Deacylase Sirtuin 5.
Sapienza University of Rome
Overview of SIRT5 as a potential therapeutic target: Structure, function and inhibitors.
China Pharmaceutical University
An in silico approach to discovering novel inhibitors of human sirtuin type 2.
University of Kuopio
Drug Repurposing of Quisinostat to Discover Novel
East China University of Science and Technology
Indirubin Derivatives as Dual Inhibitors Targeting Cyclin-Dependent Kinase and Histone Deacetylase for Treating Cancer.
Guizhou Medical University
Identification of isoform/domain-selective fragments from the selection of DNA-encoded dynamic library.
The University of Hong Kong
Discovery of Dihydro-1,4-Benzoxazine Carboxamides as Potent and Highly Selective Inhibitors of Sirtuin-1.
Max Planck Institute of Molecular Physiology
Discovery of new human Sirtuin 5 inhibitors by mimicking glutaryl-lysine substrates.
Xihua University
Single-step fluorescent probes to detect decrotonylation activity of HDACs through intramolecular reactions.
City University of Hong Kong
Simultaneous Inhibition of SIRT2 Deacetylase and Defatty-Acylase Activities via a PROTAC Strategy.
Cornell University
Dethioacylation by Sirtuins 1-3: Considerations for Drug Design Using Mechanism-Based Sirtuin Inhibition.
University of Copenhagen
A Set of Highly Sensitive Sirtuin Fluorescence Probes for Screening Small-Molecular Sirtuin Defatty-Acylase Inhibitors.
Nagoya City University
Synthesis of indole inhibitors of silent information regulator 1 (SIRT1), and their evaluation as cytotoxic agents.
Universit£
Structure activity study of S-trityl-cysteamine dimethylaminopyridine derivatives as SIRT2 inhibitors: Improvement of SIRT2 binding and inhibition.
Science Farm
Discovery of 5-Benzylidene-2-phenyl-1,3-dioxane-4,6-diones as Highly Potent and Selective SIRT1 Inhibitors.
Chinese Academy of Sciences
Sensitive fluorogenic substrates for sirtuin deacylase inhibitor discovery.
Xihua University
Recent advances in the discovery of potent and selective HDAC6 inhibitors.
Shandong University
A bicyclic pentapeptide-based highly potent and selective pan-SIRT1/2/3 inhibitor harboring N
Fudan University
Discovery of Potent Small-Molecule SIRT6 Activators: Structure-Activity Relationship and Anti-Pancreatic Ductal Adenocarcinoma Activity.
Sichuan University
Discovery of 5-(4-methylpiperazin-1-yl)-2-nitroaniline derivatives as a new class of SIRT6 inhibitors.
Sichuan University
Unexpected small molecules as novel SIRT2 suicide inhibitors.
Engineering Research Center For The Development and Application of Ethnic Medicine and Tcm (Ministry of Education)
Recent applications of hydantoin and thiohydantoin in medicinal chemistry.
College of Pharmacy and Gachon Institute of Pharmaceutical Science
An overview of Sirtuins as potential therapeutic target: Structure, function and modulators.
Sichuan University
Novel Lysine-Based Thioureas as Mechanism-Based Inhibitors of Sirtuin 2 (SIRT2) with Anticancer Activity in a Colorectal Cancer Murine Model.
TBA
Synthesis of certain benzothieno[3,2-d]pyrimidine derivatives as a selective SIRT2 inhibitors.
Cairo University
Extending Cross Metathesis To Identify Selective HDAC Inhibitors: Synthesis, Biological Activities, and Modeling.
Umr Cnrs 7285
Pharmaceutical significance of azepane based motifs for drug discovery: A critical review.
Wuhan Institute of Technology
Synthesis and in Vitro and in Vivo Biological Evaluation of Tissue-Specific Bisthiazole Histone Deacetylase (HDAC) Inhibitors.
Chinese Academy of Sciences
Identification of Diketopiperazine-Containing 2-Anilinobenzamides as Potent Sirtuin 2 (SIRT2)-Selective Inhibitors Targeting the "Selectivity Pocket", Substrate-Binding Site, and NAD
Kyoto Prefectural University of Medicine
Structure-Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from
University of Freiburg
Thienopyrimidinone Based Sirtuin-2 (SIRT2)-Selective Inhibitors Bind in the Ligand Induced Selectivity Pocket.
Imperial College
Human SIRT3 tripeptidic inhibitors containing N(?)-thioacetyl-lysine.
Jiangsu University
The Discovery of Novel 10,11-Dihydro-5H-dibenz[b,f]azepine SIRT2 Inhibitors.
Imperial College London
Development of Peptide-Based Sirtuin Defatty-Acylase Inhibitors Identified by the Fluorescence Probe, SFP3, That Can Efficiently Measure Defatty-Acylase Activity of Sirtuin.
Nagoya City University
Squaramides as novel class I and IIB histone deacetylase inhibitors for topical treatment of cutaneous t-cell lymphoma.
Nestle Skin Health R&D
Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals).
University of Freiburg
SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects.
University of Genoa
X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells.
West China School of Pharmacy
Discovery and Characterization of R/S-N-3-Cyanophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea, a New Histone Deacetylase Class III Inhibitor Exerting Antiproliferative Activity against Cancer Cell Lines.
H�Pital Kirchberg
Discovery of 2-((4,6-dimethylpyrimidin-2-yl)thio)-N-phenylacetamide derivatives as new potent and selective human sirtuin 2 inhibitors.
Xihua University
Thermodynamics of molecular recognition by cyclodextrins. 1. Calorimetric titration of inclusion complexation of naphthalenesulfonates with .alpha.-, .beta.-, and .gamma.-cyclodextrins: enthalpy-entropy compensation
Himeji Institute of Technology