BDBM50277889 CARFILZOMIB::CHEMBL451887

SMILES CC(C)C[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)CN1CCOCC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1

InChI Key InChIKey=BLMPQMFVWMYDKT-NZTKNTHTSA-N

Data  47 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50277889   

TargetProteasome subunit beta type-5(Homo sapiens (Human))
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50277889(CARFILZOMIB | CHEMBL451887)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of 20S proteasome beta5 subunit in human RPMI8226 cell lysate using Suc-LLVY-AMC as substrate pretreated for 1 hr followed by substrate ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProteasome subunit beta type-9(Homo sapiens (Human))
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50277889(CARFILZOMIB | CHEMBL451887)
Affinity DataIC50:  2.94E+3nMAssay Description:Inhibition of purified human 20S immunoproteasome beta1 subunit using Ac-Pro-Ala-Leu-AMC as substrate pretreated for 1 hr followed by substrate addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

LigandPNGBDBM50277889(CARFILZOMIB | CHEMBL451887)
Affinity DataIC50:  7nMAssay Description:Inhibition of human 20S proteasome chymotrypsin-like activity in human RPMI-8226 cells using Suc-LLVY-AMC as fluorogenic substrate incubated for 3 hr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50277889(CARFILZOMIB | CHEMBL451887)
Affinity DataIC50:  270nMAssay Description:Inhibition of human 20S proteasome chymotrypsin-like activity in human RPMI-8226 cells overexpressing ABCB1 using Suc-LLVY-AMC as fluorogenic substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed