BDBM50277889 CARFILZOMIB::CHEMBL451887

SMILES CC(C)C[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)CN1CCOCC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1

InChI Key InChIKey=BLMPQMFVWMYDKT-NZTKNTHTSA-N

Data  47 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50277889   

TargetGlutathione S-transferase omega-1(Homo sapiens (Human))
Monash University

Curated by ChEMBL

LigandBDBM50277889(CARFILZOMIB | CHEMBL451887)Copy SMILESCopy InChI

Affinity DataIC50:  150nMAssay Description:Inhibition of GSTO1-1 (unknown origin) pre-incubated for 1 hr before GSH addition by CDNB-GSH conjugation assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankMCE
PC cidPC sidPatentsSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetA5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436(Homo sapiens (Human))
Monash University

Curated by ChEMBL

LigandBDBM50277889(CARFILZOMIB | CHEMBL451887)Copy SMILESCopy InChI

Affinity DataIC50: <10nMAssay Description:Inhibition of 20S proteasome activity in human ANBL-6 cellsMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
antibodypediaantibodypediaantibodypediaantibodypediaantibodypediaantibodypediaantibodypediaantibodypediaantibodypediaGoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankMCE
PC cidPC sidPatentsSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI