BDBM50015640 GALUNISERTIB::LY-2157299

SMILES Cc1cccc(n1)-c1nn2CCCc2c1-c1ccnc2ccc(cc12)C(N)=O

InChI Key InChIKey=IVRXNBXKWIJUQB-UHFFFAOYSA-N

Data  25 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50015640   

TargetTGF-beta receptor type-1(Homo sapiens (Human))
Yanbian University

Curated by ChEMBL
LigandPNGBDBM50015640(GALUNISERTIB | LY-2157299)
Affinity DataIC50:  119nMAssay Description:Inhibition of human recombinant GST-tagged ALK5 expressed in Sf9 insect cells using casein as substrate incubated for 60 mins in presence of [33P]-AT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Yanbian University

Curated by ChEMBL
LigandPNGBDBM50015640(GALUNISERTIB | LY-2157299)
Affinity DataIC50:  490nMAssay Description:Inhibition of human recombinant untagged p38alpha expressed in Escherichia coli using ATF2 as substrate incubated for 60 mins in presence of [33P]-AT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Yanbian University

Curated by ChEMBL
LigandPNGBDBM50015640(GALUNISERTIB | LY-2157299)
Affinity DataIC50:  493nMAssay Description:Inhibition of human recombinant untagged p38alpha expressed in Escherichia coli using ATF2 as substrate incubated for 60 mins in presence of [33P]-AT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Yanbian University

Curated by ChEMBL
LigandPNGBDBM50015640(GALUNISERTIB | LY-2157299)
Affinity DataIC50:  129nMAssay Description:Inhibition of human recombinant GST-tagged ALK5 expressed in Sf9 insect cells using casein as substrate incubated for 60 mins in presence of [33P]-AT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Yanbian University

Curated by ChEMBL
LigandPNGBDBM50015640(GALUNISERTIB | LY-2157299)
Affinity DataIC50:  487nMAssay Description:Inhibition of recombinant human p38alpha expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Yanbian University

Curated by ChEMBL
LigandPNGBDBM50015640(GALUNISERTIB | LY-2157299)
Affinity DataIC50:  119nMAssay Description:Inhibition of recombinant GST-tagged human ALK5 expressed in baculovirus infected Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Yanbian University

Curated by ChEMBL
LigandPNGBDBM50015640(GALUNISERTIB | LY-2157299)
Affinity DataIC50:  493nMAssay Description:Inhibition of recombinant human p38alpha expressed in Escherichia coli assessed as incoporation of [33]Pi after 60 mins in presence of [gamma-33P]-AT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Yanbian University

Curated by ChEMBL
LigandPNGBDBM50015640(GALUNISERTIB | LY-2157299)
Affinity DataIC50:  129nMAssay Description:Inhibition of recombinant human GST-fused ALK5 expressed in baculovirus infected Sf9 cells assessed as incoporation of [33]Pi after 60 mins in presen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed