BDBM50015640 GALUNISERTIB::LY-2157299

SMILES Cc1cccc(n1)-c1nn2CCCc2c1-c1ccnc2ccc(cc12)C(N)=O

InChI Key InChIKey=IVRXNBXKWIJUQB-UHFFFAOYSA-N

Data  25 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50015640   

TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50015640(GALUNISERTIB | LY-2157299)
Affinity DataIC50:  44nMAssay Description:Inhibition of RIPK2 (unknown origin) by radioisotopic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50015640(GALUNISERTIB | LY-2157299)
Affinity DataIC50: >100nMAssay Description:Inhibition of ALK5 in human HaCaT cells assessed as inhibition of TGFbeta1-induced luciferase activity after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Mus musculus)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50015640(GALUNISERTIB | LY-2157299)
Affinity DataIC50: >100nMAssay Description:Inhibition of ALK5 in mouse 4T1 cells assessed as inhibition of TGFbeta1-induced luciferase activity after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivin receptor type-1B(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50015640(GALUNISERTIB | LY-2157299)
Affinity DataIC50:  199nMAssay Description:Inhibition of ALK4 (unknown origin) by radioisotopic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50015640(GALUNISERTIB | LY-2157299)
Affinity DataIC50:  442nMAssay Description:Inhibition of VEGFR2 (unknown origin) by radioisotopic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed