BDBM23971 (2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido]-4-methylpentanoic acid::Bestatin::CHEMBL29292::Ubenimex

SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O

InChI Key InChIKey=VGGGPCQERPFHOB-RDBSUJKOSA-N

Data  20 KI  120 IC50  3 Kd

PDB links: 26 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 23971   

TargetAminopeptidase N(Sus scrofa (Pig))
Shandong University

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of pig kidney microsomal APN assessed as hydrolysis of L-Leu-p-nitroanilide after 1 hr by spectrophotometryMore data for this Ligand-Target Pair
TargetAminopeptidase N(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  2.29E+4nMAssay Description:Inhibition of APN in human HL60 cells assessed as hydrolysis of L-Leu-p-nitroanilide by spectrophotometryMore data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM23971((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Affinity DataIC50:  1.20E+5nMAssay Description:Inhibition of human MMP-2 after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed