BindingDB BDBM29136 CHEMBL92401::Euphozid::Iprazid::Iproniazid

BDBM29136 CHEMBL92401::Euphozid::Iprazid::Iproniazid

SMILES CC(C)NNC(=O)c1ccncc1

InChI Key InChIKey=NYMGNSNKLVNMIA-UHFFFAOYSA-N

Data 3 KI 153 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 29136

Amine oxidase [flavin-containing] B(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

BDBM29136(CHEMBL92401 | Euphozid | Iprazid | Iproniazid)

IC50: 1.95E+3nMAssay Description:Inhibition of human recombinant MAO-B using kynuramine as substrate measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Purchase CHEMBL DrugBank MCE
KEGG PC cid PC sid Patents Similars

Details Article PubMed

Amine oxidase [flavin-containing] A(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL

BDBM29136(CHEMBL92401 | Euphozid | Iprazid | Iproniazid)

IC50: 2.56E+3nMAssay Description:Inhibition of human recombinant MAO-A using kynuramine as substrate measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Purchase CHEMBL DrugBank MCE
KEGG PC cid PC sid Patents Similars

Details Article PubMed

Filter my 156 hits

Targets 9▿
- Amine oxidase [flavin-containing] B 73
- Amine oxidase [flavin-containing] A 72
- Bile salt export pump 5
- ATP-binding cassette sub-family C member 3 1
- Sodium-dependent serotonin transporter 1
- ATP-binding cassette sub-family C member 4 1
- ATP-binding cassette sub-family C member 2 1
- Sodium-dependent noradrenaline transporter 1
- Sodium-dependent dopamine transporter 1
Publications 50▿
- Toxicol Sci 136: 216-41 (2013) 4
- Eur J Pharmacol 340: 249-58 (1997) 3
- Bioorg Med Chem Lett 22: 258-61 (2011) 2
- Eur J Med Chem 202: (2020) 2
- Bioorg Med Chem 22: 2887-95 (2014) 2
- Eur J Med Chem 178: 726-739 (2019) 2
- Bioorg Med Chem 25: 714-726 (2017) 2
- J Med Chem 65: 4727-4751 (2022) 2
- Bioorg Med Chem 25: 3006-3017 (2017) 2
- Eur J Med Chem 180: 238-252 (2019) 2
- Bioorg Med Chem Lett 21: 707-9 (2011) 2
- J Med Chem 51: 4874-80 (2008) 2
- Bioorg Med Chem 18: 1659-64 (2010) 2
- Bioorg Med Chem 25: 3815-3826 (2017) 2
- Bioorg Med Chem 18: 1273-9 (2010) 2
- Bioorg Med Chem 25: 1030-1041 (2017) 2
- Bioorg Med Chem 26: 1102-1115 (2018) 2
- Eur J Med Chem 157: 161-176 (2018) 2
- Eur J Med Chem 126: 762-775 (2017) 2
- Eur J Med Chem 95: 153-65 (2015) 2
- Bioorg Med Chem 35: (2021) 2
- Eur J Med Chem 46: 5838-51 (2011) 2
- Bioorg Med Chem Lett 19: 3268-70 (2009) 2
- Eur J Med Chem 59: 91-100 (2013) 2
- Eur J Med Chem 58: 405-17 (2012) 2
- Bioorg Med Chem Lett 20: 6479-82 (2010) 2
- Bioorg Med Chem 24: 5929-5940 (2016) 2
- J Nat Prod 80: 798-804 (2017) 2
- Eur J Med Chem 121: 376-386 (2016) 2
- Bioorg Med Chem Lett 27: 5053-5059 (2017) 2
- Eur J Med Chem 117: 292-300 (2016) 2
- Bioorg Med Chem Lett 27: 5046-5052 (2017) 2
- Bioorg Med Chem Lett 20: 2709-12 (2010) 2
- Bioorg Med Chem 28: (2020) 2
- Bioorg Med Chem 28: (2020) 2
- Bioorg Med Chem Lett 25: 508-13 (2015) 2
- J Med Chem 53: 6516-20 (2010) 2
- Bioorg Chem 71: 305-314 (2017) 2
- Bioorg Med Chem 18: 5715-23 (2010) 2
- Eur J Med Chem 163: 307-319 (2019) 2
- J Med Chem 52: 2818-24 (2009) 2
- Bioorg Med Chem 26: 1885-1895 (2018) 2
- Bioorg Med Chem 22: 3732-8 (2014) 2
- Bioorg Med Chem Lett 27: 718-722 (2017) 2
- Bioorg Med Chem Lett 23: 5128-30 (2013) 2
- Bioorg Med Chem Lett 19: 5053-5 (2009) 2
- Bioorg Med Chem 18: 5063-70 (2010) 2
- Eur J Med Chem 139: 48-59 (2017) 2
- Eur J Med Chem 139: 1-11 (2017) 2
- Eur J Med Chem 156: 534-553 (2018) 2
- ...
Institutions 22▿
- Sapienza University Of Rome 18
- Sichuan University 14
- China Pharmaceutical University 10
- Nanyang Normal University 10
- Universit£ 8
- Guizhou Medical University 6
- Amgen 4
- Instituto De Qu£Mica M£Dica 4
- Mayo Clinic 3
- Universidad De Santiago De Compostela 2
- Anhui Medical University 2
- Universidade De Vigo 2
- Consejo Superior De Investigaciones Cient�Ficas (Iqm-Csic) 2
- University Of Santiago De Compostela 2
- Facultad De Farmacia 2
- Sapienza University of Rome 2
- Universidade Do Porto 2
- School of Traditional Chinese Pharmacy 2
- Shanghai University of Traditional Chinese Medicine 2
- Nanjing University 2
- Yunnan University 2
- Affiated Tumor Hospital Of Guangxi Medical University 2
- ...
Affinity: 7.5 to 1.0E+6 nM▿
- Ki 3
- IC50 153
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1