BDBM50015640 GALUNISERTIB::LY-2157299
SMILES Cc1cccc(n1)-c1nn2CCCc2c1-c1ccnc2ccc(cc12)C(N)=O
InChI Key InChIKey=IVRXNBXKWIJUQB-UHFFFAOYSA-N
Data 25 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 25 hits for monomerid = 50015640
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Ewha Womans University
Curated by ChEMBL
Ewha Womans University
Curated by ChEMBL
Affinity DataIC50: 44nMAssay Description:Inhibition of RIPK2 (unknown origin) by radioisotopic assayMore data for this Ligand-Target Pair
Affinity DataIC50: 56nMAssay Description:Inhibition of TGF-beta (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >100nMAssay Description:Inhibition of ALK5 in human HaCaT cells assessed as inhibition of TGFbeta1-induced luciferase activity after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: >100nMAssay Description:Inhibition of ALK5 in mouse 4T1 cells assessed as inhibition of TGFbeta1-induced luciferase activity after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 199nMAssay Description:Inhibition of ALK4 (unknown origin) by radioisotopic assayMore data for this Ligand-Target Pair
Affinity DataIC50: 69nMAssay Description:Inhibition of human recombinant GST-fused ALK5 expressed in Sf9 insect cells using casein as substrate by proprietary radioisotopic protein kinase as...More data for this Ligand-Target Pair
Affinity DataIC50: 405nMAssay Description:Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as substrate by proprietary radioisotopic protein kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of wild type His-tagged TGFbetaR2 (unknown origin) after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.10nMAssay Description:Inhibition of human His-tagged TGFbetaR1 T204D mutant expressed in Sf9 insect cells after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 51nMAssay Description:Inhibition of human ALK5 expressed in Sf9 insect cells using casein as substrate in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 119nMAssay Description:Inhibition of human recombinant GST-tagged ALK5 expressed in Sf9 insect cells using casein as substrate incubated for 60 mins in presence of [33P]-AT...More data for this Ligand-Target Pair
Affinity DataIC50: 490nMAssay Description:Inhibition of human recombinant untagged p38alpha expressed in Escherichia coli using ATF2 as substrate incubated for 60 mins in presence of [33P]-AT...More data for this Ligand-Target Pair
Affinity DataIC50: 56nMAssay Description:Inhibition of TGFBR1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 493nMAssay Description:Inhibition of human recombinant untagged p38alpha expressed in Escherichia coli using ATF2 as substrate incubated for 60 mins in presence of [33P]-AT...More data for this Ligand-Target Pair
Affinity DataIC50: 129nMAssay Description:Inhibition of human recombinant GST-tagged ALK5 expressed in Sf9 insect cells using casein as substrate incubated for 60 mins in presence of [33P]-AT...More data for this Ligand-Target Pair
Affinity DataIC50: 487nMAssay Description:Inhibition of recombinant human p38alpha expressed in Escherichia coliMore data for this Ligand-Target Pair
Affinity DataIC50: 119nMAssay Description:Inhibition of recombinant GST-tagged human ALK5 expressed in baculovirus infected Sf9 insect cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 493nMAssay Description:Inhibition of recombinant human p38alpha expressed in Escherichia coli assessed as incoporation of [33]Pi after 60 mins in presence of [gamma-33P]-AT...More data for this Ligand-Target Pair
Affinity DataIC50: 129nMAssay Description:Inhibition of recombinant human GST-fused ALK5 expressed in baculovirus infected Sf9 cells assessed as incoporation of [33]Pi after 60 mins in presen...More data for this Ligand-Target Pair
Affinity DataIC50: 56nMAssay Description:Inhibition of TbetaR-1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 127nMAssay Description:Inhibition of human TGFbeta receptor 1 in human HEK293 cells preincubated for 24 hrs followed by addition of TGFbeta1 and measured after 24 hrs by lu...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
University Of Arkansas For Medical Sciences
Curated by ChEMBL
University Of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 263nMAssay Description:Inhibition of recombinant human GST-tagged MAP4K4 expressed in baculovirus expression system using 5-FAM-KRELVEPLTPSGEAPNQALLR-CONH2 substrate preinc...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
University Of Arkansas For Medical Sciences
Curated by ChEMBL
University Of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 280nMAssay Description:Inhibition of wild type partial length human MAP4K4 (M1 to R310 residues) expressed in bacterial expression system measured by Kinomescan assayMore data for this Ligand-Target Pair
Affinity DataIC50: 170nMAssay Description:Inhibition of human TGF-beta-R1 using TMB substrate incubated for 2.5 hrs by microplate reader analysisMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Ewha Womans University
Curated by ChEMBL
Ewha Womans University
Curated by ChEMBL
Affinity DataIC50: 442nMAssay Description:Inhibition of VEGFR2 (unknown origin) by radioisotopic assayMore data for this Ligand-Target Pair