BDBM10308 5-(azetidine-1-sulfonyl)-2,3-dihydro-1H-indole-2,3-dione::5-[1-(Azetidinyl)sulfonyl]isatin::Isatin Sulfonamide 19

SMILES O=C1Nc2ccc(cc2C1=O)S(=O)(=O)N1CCC1

InChI Key InChIKey=VEHTUFDNCGHBFH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 10308   

TargetCaspase-3(Homo sapiens (Human))
Osmania University College For Women

Curated by ChEMBL
LigandPNGBDBM10308(5-(azetidine-1-sulfonyl)-2,3-dihydro-1H-indole-2,3...)
Affinity DataIC50:  170nMAssay Description:Inhibition of caspase 3 in human SK-N-SH cells assessed as accumulation of fluorogenic 7-amino-4-methyl coumarin by flurometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Osmania University College For Women

Curated by ChEMBL
LigandPNGBDBM10308(5-(azetidine-1-sulfonyl)-2,3-dihydro-1H-indole-2,3...)
Affinity DataIC50:  170nMpH: 7.5 T: 2°CAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed