BDBM11835 1-(3-{6-[(cyclopropylmethyl)amino]imidazo[1,2-a]pyridazin-3-yl}phenyl)ethan-1-one::CHEMBL200528::Cancer Res 676916 Compound K00135::Imidazol[1,2-b]pyridazine 1

SMILES CC(=O)c1cccc(c1)-c1cnc2ccc(NCC3CC3)nn12

InChI Key InChIKey=IVUBNTNWKIPCPS-UHFFFAOYSA-N

Data  6 IC50  1 Kd  1 ITC

PDB links: 3 PDB IDs match this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 11835   

TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
University Hospital Basel

LigandPNGBDBM11835(1-(3-{6-[(cyclopropylmethyl)amino]imidazo[1,2-a]py...)
Affinity DataIC50:  120nMpH: 7.5 T: 2°CAssay Description:Phosphorylation reactions were monitored using a coupled-enzyme assay in which ADP production was coupled to NADH oxidation by pyruvate kinase and la...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
University Hospital Basel

LigandPNGBDBM11835(1-(3-{6-[(cyclopropylmethyl)amino]imidazo[1,2-a]py...)
Affinity DataIC50:  1.80E+3nMpH: 7.5 T: 2°CAssay Description:Phosphorylation reactions were monitored using a coupled-enzyme assay in which ADP production was coupled to NADH oxidation by pyruvate kinase and la...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
University Hospital Basel

LigandPNGBDBM11835(1-(3-{6-[(cyclopropylmethyl)amino]imidazo[1,2-a]py...)
Affinity DataKd:  25nMAssay Description:Binding affinity to non phosphorylated PIM1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
University Hospital Basel

LigandPNGBDBM11835(1-(3-{6-[(cyclopropylmethyl)amino]imidazo[1,2-a]py...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of PIM2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
University Hospital Basel

LigandPNGBDBM11835(1-(3-{6-[(cyclopropylmethyl)amino]imidazo[1,2-a]py...)
Affinity DataIC50:  61nMAssay Description:Inhibition of Pim1 (unknown origin) assessed as [32P] incorporation preincubated for 15 mins before ATP substrate addition by coupled spectrophotomet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
University Hospital Basel

LigandPNGBDBM11835(1-(3-{6-[(cyclopropylmethyl)amino]imidazo[1,2-a]py...)
Affinity DataIC50:  12nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
University Hospital Basel

LigandPNGBDBM11835(1-(3-{6-[(cyclopropylmethyl)amino]imidazo[1,2-a]py...)
Affinity DataIC50:  61nMAssay Description:Inhibitory activity against PIM1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Activity Spreadsheet -- ITC Data from BindingDB

Found 1 hit for monomerid = 11835   

CellPNGBDBM11835(1-(3-{6-[(cyclopropylmethyl)amino]imidazo[1,2-a]py...)
Oxford University

SyringeSerine/threonine-protein kinase PIM(Homo sapiens (Human))
ITC DataΔG°: -9.78kcal/mole −TΔS°: -4.66kcal/mole ΔH°: -5.19kcal/mole logk: 3.97E+7
pH: 7.5 T: 10.00°C