BDBM122528 US8729061, 58

SMILES CC(C)[C@H](NC(=O)[C@@H]1C[C@H](CN1C(=O)C1(CC1)c1ncc(Cl)cc1F)S(=O)(=O)c1ccccc1Cl)C(=O)C(=O)NC1CC1

InChI Key InChIKey=ZZPFZJXGGZUTHR-JZWVFAODSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 122528   

TargetCathepsin S(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM122528(US8729061, 58)
Affinity DataIC50:  0.478nMpH: 6.5Assay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCathepsin B(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM122528(US8729061, 58)
Affinity DataIC50:  323nMpH: 6.5Assay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCathepsin K(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM122528(US8729061, 58)
Affinity DataIC50:  49.1nMpH: 6.5Assay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProcathepsin L(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM122528(US8729061, 58)
Affinity DataIC50:  0.900nMpH: 6.5Assay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In DepthDetails US Patent