BDBM127373 US8791131, 131

SMILES COc1ccc(cn1)-c1ccc2ncc3[nH]c(=O)n([C@H]4CC[C@@H](CC4)OCCO)c3c2n1

InChI Key InChIKey=JFXLBGOSVVDUOC-WKILWMFISA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 127373   

LigandPNGBDBM127373(US8791131, 131)
Affinity DataKi:  0.644nM ΔG°:  -12.5kcal/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM127373(US8791131, 131)
Affinity DataKi:  2.14nM ΔG°:  -11.8kcal/molepH: 7.5 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...More data for this Ligand-Target Pair
In DepthDetails US Patent