BDBM127480 US8791131, 256

SMILES Cn1c2cnc3ccc(nc3c2n(C2CCN(CC2)C(=O)CO)c1=O)-c1cccc2[nH]ncc12

InChI Key InChIKey=OYXDADGCFDOKLT-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 127480   

LigandPNGBDBM127480(US8791131, 256)
Affinity DataKi:  0.575nM ΔG°:  -12.6kcal/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM127480(US8791131, 256)
Affinity DataKi:  1.97nM ΔG°:  -11.9kcal/molepH: 7.5 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...More data for this Ligand-Target Pair
In DepthDetails US Patent