BDBM127484 US8791131, 262

SMILES Cn1c2cnc3ccc(nc3c2n(C2CCN(CC2)C(=O)CO)c1=O)-c1cnc2[nH]ncc2c1

InChI Key InChIKey=HNHGXYRBEMGQQH-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 127484   

LigandPNGBDBM127484(US8791131, 262)
Affinity DataKi:  0.320nM ΔG°:  -12.9kcal/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM127484(US8791131, 262)
Affinity DataKi:  4.06nM ΔG°:  -11.4kcal/molepH: 7.5 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...More data for this Ligand-Target Pair
In DepthDetails US Patent