BDBM130909 US10683289, Example Staurosporine::US10927120, Compound staurosporine::US8822500, Stauro- sporine::US9920060, Staurosporine

SMILES CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13

InChI Key InChIKey=HKSZLNNOFSGOKW-UHFFFAOYSA-N

Data  13 IC50

PDB links: 88 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 130909   

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Homo sapiens (Human))
Gi Therapeutics

US Patent

LigandBDBM130909(US10683289, Example Staurosporine | US10927120, Co...)Copy SMILESCopy InChI

Affinity DataIC50:  37.5nMAssay Description:For the measurement of CDK2/cyclinE activity, enzyme (0.22 nM) was incubated with 100 mM ATP and the phosphoacceptor substrate peptide (1 mM) for one...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

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In DepthDetails US Patent
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TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Gi Therapeutics

US Patent

LigandBDBM130909(US10683289, Example Staurosporine | US10927120, Co...)Copy SMILESCopy InChI

Affinity DataIC50:  3.93nMAssay Description:For the measurement of CDK2/cyclinE activity, enzyme (0.22 nM) was incubated with 100 mM ATP and the phosphoacceptor substrate peptide (1 mM) for one...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPDBSimilars

In DepthDetails US PatentPDB3D Structure (crystal)
Copy BDB DOI