BDBM144453 US10947243, Example 4::US8969568, 4::US9914735, Example 4

SMILES COc1cc(ccc1OC(F)(F)F)-c1cc2ncccc2c(O[C@H](C)[C@H]2CNC(=O)C2)n1

InChI Key InChIKey=IWADCUQKACLNKJ-TZMCWYRMSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 144453   

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Boehringer Ingelheim Pharma

US Patent
LigandPNGBDBM144453(US10947243, Example 4 | US8969568, 4 | US9914735, ...)
Affinity DataIC50:  1.90nMAssay Description:Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Boehringer Ingelheim Pharma

US Patent
LigandPNGBDBM144453(US10947243, Example 4 | US8969568, 4 | US9914735, ...)
Affinity DataIC50:  3nMAssay Description:Human GSK3beta (expressed and prified from SF21 cells) is obtained from the University Dundee/Scotland (Dr. James Hastie—Dept. of Biochemistry) ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM144453(US10947243, Example 4 | US8969568, 4 | US9914735, ...)
Affinity DataIC50:  1.85E+3nMAssay Description:Recombinant human Aurora B (amino acids 1-344, clone number DU1773, Molecular weight 40.2 kDa, University of Dundee) was expressed as a fusion protei...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM144453(US10947243, Example 4 | US8969568, 4 | US9914735, ...)
Affinity DataIC50:  633nMAssay Description:FLT3 is obtained from Invitrogen in 50 mM Tris (pH7.5); 100 mM NaCl; 0.05 mM EDTA, 0.05% NP-40, 2 mM DTT; 50% Glycerol # PV3182; Lot 286671; sequence...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM144453(US10947243, Example 4 | US8969568, 4 | US9914735, ...)
Affinity DataIC50: >1.00E+4nMAssay Description:FLT3 is obtained from Invitrogen in 50 mM Tris (pH7.5); 100 mM NaCl; 0.05 mM EDTA, 0.05% NP-40, 2 mM DTT; 50% Glycerol # PV3182; Lot 286671; sequence...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK [342-635](Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM144453(US10947243, Example 4 | US8969568, 4 | US9914735, ...)
Affinity DataIC50:  3nMAssay Description:Human GSK3beta (expressed and prified from SF21 cells) is obtained from the University Dundee/Scotland (Dr. James Hastie—Dept. of Biochemistry) in 50...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM144453(US10947243, Example 4 | US8969568, 4 | US9914735, ...)
Affinity DataIC50:  1.85E+3nMAssay Description:Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM144453(US10947243, Example 4 | US8969568, 4 | US9914735, ...)
Affinity DataIC50:  633nMAssay Description:Recombinant human Aurora B (amino acids 1-344, clone number DU1773, Molecular weight 40.2 kDa, University of Dundee) was expressed as a fusion protei...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM144453(US10947243, Example 4 | US8969568, 4 | US9914735, ...)
Affinity DataIC50: >1.00E+4nMAssay Description:Human GSK3beta (expressed and prified from SF21 cells) is obtained from the University Dundee/Scotland (Dr. James Hastie—Dept. of Biochemistry) ...More data for this Ligand-Target Pair
In DepthDetails US Patent