BDBM147539 US8962608, 17-20

SMILES NC(=O)c1cn(nc1Nc1ccc2C(=O)N(CC(F)(F)F)Cc2c1)[C@H]1CCCC[C@@H]1C#N

InChI Key InChIKey=MJOUHJKBMTXVKJ-PXAZEXFGSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 147539   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM147539(US8962608, 17-20)
Affinity DataIC50:  0.790nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM147539(US8962608, 17-20)
Affinity DataIC50:  0.170nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In DepthDetails US Patent