BDBM148414 US9682963, 7
SMILES CN(C1CCOC1=O)c1ccc(NC(=O)c2cccc(c2)-c2cc(ccc2CN)C(=O)Nc2ccncc2F)cc1
InChI Key InChIKey=RATUMGRAXCWNBG-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 148414
Affinity DataIC50: <100nMpH: 7.5 T: 2°CAssay Description:Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO. Required cofactor...More data for this Ligand-Target Pair
Affinity DataEC50: <100nMAssay Description:Rat smooth muscle cell line A7r5 is used. The endogenous expression of ROCK results in a constitutive phosphorylation of the regulatory myosin light ...More data for this Ligand-Target Pair