BDBM151977 US8987457, 171

SMILES C[C@H]1C[C@H](C[C@@H](N)[C@H]1n1ccnn1)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(OC2CCOCC2)cc1F

InChI Key InChIKey=BLHWEGXFMWEIHN-ZYQIVFPSSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 151977   

TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM151977(US8987457, 171)
Affinity DataIC50:  2.51nMAssay Description:Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM151977(US8987457, 171)
Affinity DataIC50:  10.2nMAssay Description:Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM151977(US8987457, 171)
Affinity DataIC50:  0.0200nMAssay Description:Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...More data for this Ligand-Target Pair
In DepthDetails US Patent