BDBM15457 2-(4-fluorophenyl)-4-methoxy-3-(pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-6-amine::2-(4-fluorophenyl)-4-methoxy-3-pyridin-4-yl-1H-pyrrolo[2,3-b]pyridin-6-amine::CHEMBL115769::RWJ-68354

SMILES COc1cc(N)nc2[nH]c(c(-c3ccncc3)c12)-c1ccc(F)cc1

InChI Key InChIKey=ADQZGIYHFQQPRB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 15457   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM15457(2-(4-fluorophenyl)-4-methoxy-3-(pyridin-4-yl)-1H-p...)
Affinity DataIC50:  52nMAssay Description:The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM15457(2-(4-fluorophenyl)-4-methoxy-3-(pyridin-4-yl)-1H-p...)
Affinity DataIC50:  7nMAssay Description:Inhibition of LPS-induced p38-related TNF-alpha production in human peripheral blood mononuclear cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM15457(2-(4-fluorophenyl)-4-methoxy-3-(pyridin-4-yl)-1H-p...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of murine p38 alpha kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed