BDBM154588 US8999957, Column 141, Compound 4::US8999957, Table 1, Compound 12

SMILES Fc1ccccc1CN1CCC[C@H](C1)NC(=O)c1ccc2[nH]nc(-c3ccnc(Cl)c3)c2c1

InChI Key

Data  4 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 154588   

TargetMitogen-activated protein kinase 3(Mus musculus (Mouse))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154588(US8999957, Column 141, Compound 4 | US8999957, Tab...)
Affinity DataKd:  0.580nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Mus musculus (Mouse))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154588(US8999957, Column 141, Compound 4 | US8999957, Tab...)
Affinity DataIC50:  25nMpH: 7.2 T: 2°CAssay Description:Activity of compounds against inactive ERK2 was tested in a coupled MEK1/ERK2 IMAP assay as follows: Compounds were diluted to 25x final test concent...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Mus musculus (Mouse))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154588(US8999957, Column 141, Compound 4 | US8999957, Tab...)
Affinity DataIC50:  26.1nMAssay Description:Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase 3(Mus musculus (Mouse))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154588(US8999957, Column 141, Compound 4 | US8999957, Tab...)
Affinity DataKd:  0.580nMAssay Description:The SAR (Structure Activity Relationship) for ERK ligands covered by this invention was interrogated using the TdF (Temperature Dependence Fluorescen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Mus musculus (Mouse))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154588(US8999957, Column 141, Compound 4 | US8999957, Tab...)
Affinity DataIC50:  25nMpH: 7.2 T: 2°CAssay Description:Activity of compounds against inactive ERK2 was tested in a coupled MEK1/ERK2 IMAP assay as follows: Compounds were diluted to 25x final test concent...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Mus musculus (Mouse))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM154588(US8999957, Column 141, Compound 4 | US8999957, Tab...)
Affinity DataIC50:  26.1nMAssay Description:Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a...More data for this Ligand-Target Pair
In DepthDetails US Patent