BDBM156189 US9018214, 240

SMILES C[C@@H]1CN(CC(=O)N2CC(C)(C)c3ncc(Cc4ccc(F)cc4)cc23)[C@@H](CN2CCOC[C@@H]2C)CN1

InChI Key InChIKey=XIQKDUKFFKQZAO-TYBLODHISA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 156189   

TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Astex Therapeutics

US Patent
LigandPNGBDBM156189(US9018214, 240)
Affinity DataIC50:  88nMpH: 7.5 T: 2°CAssay Description:Modified SMAC peptides and compounds were tested for their ability to displace the fluorescent tracer from either XIAP, clAP-1 or clAP-2. BIR3 domain...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBaculoviral IAP repeat-containing protein 2(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM156189(US9018214, 240)
Affinity DataEC50:  2.40nMAssay Description:Induction of cIAP1 degradation in human MDA-MB-231 cells after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Astex Therapeutics

US Patent
LigandPNGBDBM156189(US9018214, 240)
Affinity DataEC50:  37nMAssay Description:Inhibition of full length FLAG-tagged XIAP (unknown origin) interaction with full length untagged caspase-9 expressed in HEK293 cells after 2 hrs by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed