BDBM15793 (1S,2R)-N-[1-(3,5-Difluorobenzyl)-2-hydroxy-3-(R)-(1-isobutylcarbamoyl-ethylamino)-propyl]-N,N-dipropyl-isophthalamide::3-N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-{[(1R)-1-[(2-methylpropyl)carbamoyl]ethyl]amino}butan-2-yl]-1-N,1-N-dipropylbenzene-1,3-dicarboxamide::hydroxyethyl secondary amine (HEA) inhibitor 3b

SMILES CCCN(CCC)C(=O)c1cccc(c1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CN[C@H](C)C(=O)NCC(C)C

InChI Key InChIKey=SRFCEZYLYMKEJM-AOLGGSBGSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 15793   

TargetBeta-secretase 1(Homo sapiens (Human))
Elan Pharmaceuticals

LigandPNGBDBM15793((1S,2R)-N-[1-(3,5-Difluorobenzyl)-2-hydroxy-3-(R)-...)
Affinity DataIC50:  500nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed