BDBM161088 US9108951, 100::US9394276, 100::US9725435, 100

SMILES OC(=O)c1ccc(NC(=O)C2N(CCc3ncc(NC(=O)Nc4ccc(Cl)cc4)cc23)C(=O)\C=C\c2cc(Cl)ccc2-n2cnnn2)cc1

InChI Key InChIKey=GIIMCXNADXNBEK-KGVSQERTSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 161088   

TargetCoagulation factor XI(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM161088(US9108951, 100 | US9394276, 100 | US9725435, 100)
Affinity DataKi:  258nMAssay Description:The effectiveness of compounds of the present invention as inhibitors of the coagulation factors XIa, Vila, IXa, Xa, Xlla, plasma kallikrein or throm...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM161088(US9108951, 100 | US9394276, 100 | US9725435, 100)
Affinity DataKi:  258nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 145 mM NaCl, 5 mM KCl, and 0.1% PEG 8000 (polyethylene glycol; JT Bake...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM161088(US9108951, 100 | US9394276, 100 | US9725435, 100)
Affinity DataKi:  258nMpH: 7.4Assay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 145 mM NaCl, 5 mM KCl, and 0.1% PEG 8000 (polyethylene glycol; JT Bake...More data for this Ligand-Target Pair
In DepthDetails US Patent