BDBM161462 US10835536, Ref. Ex. Comp 3::US10894048, Ref. Ex Comp. 3::US9108973, Ref 3

SMILES CCC(=O)N1CC[C@@H](C1)n1nc(C#Cc2cc(OC)cc(OC)c2)c2c(N)ncnc12

InChI Key InChIKey=DZLNAZQOANZLHT-HNNXBMFYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 161462   

TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161462(US10835536, Ref. Ex. Comp 3 | US10894048, Ref. Ex ...)
Affinity DataIC50:  190nMpH: 7.5 T: 2°CAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161462(US10835536, Ref. Ex. Comp 3 | US10894048, Ref. Ex ...)
Affinity DataIC50:  190nMAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM161462(US10835536, Ref. Ex. Comp 3 | US10894048, Ref. Ex ...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of recombinant human EGFR del19/T790M using biotinEEPLYWSFPAKKK-NH2 as substrate incubated for 120 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161462(US10835536, Ref. Ex. Comp 3 | US10894048, Ref. Ex ...)
Affinity DataIC50:  244nMAssay Description:Inhibition of human recombinant cytoplasmic domain FGFR2 (8 to 134 residues) incubated for 120 mins by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM161462(US10835536, Ref. Ex. Comp 3 | US10894048, Ref. Ex ...)
Affinity DataIC50:  190nMAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...More data for this Ligand-Target Pair
In DepthDetails US Patent