BDBM16745 CHEMBL381617::Coumarin Compound, 10c::N-[2-(4-benzylpiperazin-1-yl)-5-bromophenyl]-8-methoxy-2-oxo-2H-chromene-3-carboxamide

SMILES COc1cccc2cc(C(=O)Nc3cc(Br)ccc3N3CCN(Cc4ccccc4)CC3)c(=O)oc12

InChI Key InChIKey=ZKEDQDYNSHAHAO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 16745   

TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16745(CHEMBL381617 | Coumarin Compound, 10c | N-[2-(4-be...)
Affinity DataIC50: >5.00E+3nMAssay Description:These experiments have been preformed using BACE-1 FRET assay kit (PanVera Corporation, Madison, WI), using a multiwell spectrofluorometer instrument...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16745(CHEMBL381617 | Coumarin Compound, 10c | N-[2-(4-be...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16745(CHEMBL381617 | Coumarin Compound, 10c | N-[2-(4-be...)
Affinity DataIC50:  5.50E+3nMAssay Description:Inhibition of BACE1 activity by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed