BDBM168216 US9669031, 181 3,3-dimethyl-1,5-dioxo-6-(pyrimidin-4-ylamino)-2H-imidazo[1,5-a]pyridine-8-carbonitrile (Cpd. No. 181)::US9669031, 47 8-chloro-3,3-dimethyl-6-(pyrimidin-4-ylamino)-2,3-dihydroimidazo[1,5-a]pyridine-1,5-dione (Cpd. No. 47)::US9669031, 71 8-ethyl-3,3-dimethyl-6-(pyrimidin-4-ylamino)-2H-imidazo[1,5-a]pyridine-1,5-dione (Cpd. No. 71)::US9669031, 79 3,3-dimethyl-6-(pyrimidin-4-ylamino)-8-vinyl-2H-imidazo[1,5-a]pyridine-1,5-dione (Cpd. No. 79)

SMILES CC1(C)NC(=O)c2c(Cl)cc(Nc3ccncn3)c(=O)n12

InChI Key InChIKey=VMPOUPXTRIFPLU-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 168216   

TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Effector Therapeutics

US Patent
LigandPNGBDBM168216(US9669031, 181 3,3-dimethyl-1,5-dioxo-6-(pyrimidin...)
Affinity DataIC50: <10nMT: 2°CAssay Description:Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Effector Therapeutics

US Patent
LigandPNGBDBM168216(US9669031, 181 3,3-dimethyl-1,5-dioxo-6-(pyrimidin...)
Affinity DataIC50: <10nMT: 2°CAssay Description:Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Effector Therapeutics

US Patent
LigandPNGBDBM168216(US9669031, 181 3,3-dimethyl-1,5-dioxo-6-(pyrimidin...)
Affinity DataIC50: >100nMT: 2°CAssay Description:Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Effector Therapeutics

US Patent
LigandPNGBDBM168216(US9669031, 181 3,3-dimethyl-1,5-dioxo-6-(pyrimidin...)
Affinity DataIC50: >100nMT: 2°CAssay Description:Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Effector Therapeutics

US Patent
LigandPNGBDBM168216(US9669031, 181 3,3-dimethyl-1,5-dioxo-6-(pyrimidin...)
Affinity DataIC50:  55nMT: 2°CAssay Description:Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMAP kinase-interacting serine/threonine-protein kinase 1/2(Homo sapiens (Human))
Effector Therapeutics

Curated by ChEMBL
LigandPNGBDBM168216(US9669031, 181 3,3-dimethyl-1,5-dioxo-6-(pyrimidin...)
Affinity DataIC50:  73nMAssay Description:Inhibition of MNK1/2 in human HCT116 cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Effector Therapeutics

US Patent
LigandPNGBDBM168216(US9669031, 181 3,3-dimethyl-1,5-dioxo-6-(pyrimidin...)
Affinity DataIC50:  55nMT: 2°CAssay Description:Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Effector Therapeutics

US Patent
LigandPNGBDBM168216(US9669031, 181 3,3-dimethyl-1,5-dioxo-6-(pyrimidin...)
Affinity DataIC50:  55nMT: 2°CAssay Description:Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Effector Therapeutics

US Patent
LigandPNGBDBM168216(US9669031, 181 3,3-dimethyl-1,5-dioxo-6-(pyrimidin...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of full length GST-tagged recombinant human MNK1 expressed in insect cells using Ac-TATKSGSTTKNR-NH2 as substrate preincubated for 5 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Effector Therapeutics

US Patent
LigandPNGBDBM168216(US9669031, 181 3,3-dimethyl-1,5-dioxo-6-(pyrimidin...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of full length N-terminal GST-tagged recombinant human MNK2 expressed in baculovirus expression system using Ac-TATKSGSTTKNR-NH2 as substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Effector Therapeutics

US Patent
LigandPNGBDBM168216(US9669031, 181 3,3-dimethyl-1,5-dioxo-6-(pyrimidin...)
Affinity DataIC50: <10nMT: 2°CAssay Description:Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent