BDBM17471 1,2,3-triazole analogue, 27::3-(1H-1,2,3-triazol-5-yl)pyridine

SMILES c1[nH]nnc1-c1cccnc1

InChI Key InChIKey=VYXFEFOIYPNBFK-UHFFFAOYSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 17471   

TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Gsk

LigandPNGBDBM17471(1,2,3-triazole analogue, 27 | 3-(1H-1,2,3-triazol-...)
Affinity DataKi:  260nM ΔG°:  -8.89kcal/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Ludwig Center For Cancer Research Of The University Of Lausanne

Curated by ChEMBL
LigandPNGBDBM17471(1,2,3-triazole analogue, 27 | 3-(1H-1,2,3-triazol-...)
Affinity DataIC50:  1.00E+6nMpH: 6.5Assay Description:Inhibition of human recombinant N-terminal His-tagged IDO1 (Ala2 to Gly403) overexpressed in Escherichia coli BL21 at pH 6.5 after 60 mins by HPLC an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM17471(1,2,3-triazole analogue, 27 | 3-(1H-1,2,3-triazol-...)
Affinity DataIC50:  3.80E+4nMAssay Description:Inhibition of human SIRT3 expressed in Escherichia coli using Z-MAL as substrate after 6 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Ludwig Center For Cancer Research Of The University Of Lausanne

Curated by ChEMBL
LigandPNGBDBM17471(1,2,3-triazole analogue, 27 | 3-(1H-1,2,3-triazol-...)
Affinity DataIC50:  7.08E+5nMAssay Description:Inhibition of human recombinant indoleamine-2,3-dioxygenase expressed in Escherichia coli BL21 using L-tryptophan as substrate after 30 mins by micro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Ludwig Center For Cancer Research Of The University Of Lausanne

Curated by ChEMBL
LigandPNGBDBM17471(1,2,3-triazole analogue, 27 | 3-(1H-1,2,3-triazol-...)
Affinity DataIC50:  6.80E+5nMAssay Description:Inhibition of human recombinant IDO expressed in Escherichia coli BL21 AIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed