BDBM179446 US9676701, 4 4′-((trans)-2-aminocyclopropyl)biphenyl-3-ol hydrochloride

SMILES N[C@H]1C[C@@H]1c1ccc(cc1)-c1cccc(O)c1

InChI Key InChIKey=DSOJSZXQRJGBCW-CABCVRRESA-N

Data  3 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 179446   

TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Oryzon Genomics

US Patent
LigandPNGBDBM179446(US9676701, 4 4′-((trans)-2-aminocyclopropyl)...)
Affinity DataKi:  50nM ΔG°:  -9.95kcal/molepH: 7.4 T: 2°CAssay Description:Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Oryzon Genomics

US Patent
LigandPNGBDBM179446(US9676701, 4 4′-((trans)-2-aminocyclopropyl)...)
Affinity DataKi: >1.00E+3nMpH: 7.5Assay Description:Assays were conducted in 96-well black plates with clear bottom (Corning) in a final volume of 100 μL. The assay buffer was 100 mM HEPES, pH 7.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Oryzon Genomics

US Patent
LigandPNGBDBM179446(US9676701, 4 4′-((trans)-2-aminocyclopropyl)...)
Affinity DataKi: >1.00E+3nMpH: 7.5Assay Description:Assays were conducted in 96-well black plates with clear bottom (Corning) in a final volume of 100 μL. The assay buffer was 100 mM HEPES, pH 7.5...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Oryzon Genomics

US Patent
LigandPNGBDBM179446(US9676701, 4 4′-((trans)-2-aminocyclopropyl)...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human recombinant LSD1 (158 to end residues) expressed in Escherichia coli using dimethylated H3K4 peptide as substrate by horseradish ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Oryzon Genomics

US Patent
LigandPNGBDBM179446(US9676701, 4 4′-((trans)-2-aminocyclopropyl)...)
Affinity DataIC50:  20nMAssay Description:Inhibition of LSD1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed