BDBM180271 US9133162, Example 2

SMILES C[C@@H](O)COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)cc3F)ccnc2c1

InChI Key InChIKey=NNVFVZWTQYUWJO-GOSISDBHSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 180271   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM180271(US9133162, Example 2)
Affinity DataIC50:  23nMpH: 7.0 T: 2°CAssay Description:KDR (h) is incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.33 mg/mL myelin basic protein, 10 mM MgAcetate and [γ-33P-ATP] (specific activity app...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sunshine Lake Pharma

US Patent
LigandPNGBDBM180271(US9133162, Example 2)
Affinity DataIC50:  7nMpH: 7.0 T: 2°CAssay Description:Met (h) is incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKSPGEYVNIEFG, 10 mM MgAcetate and [γ-33P-ATP] (specific activity approx. ...More data for this Ligand-Target Pair
In DepthDetails US Patent