BDBM18492 6-methyl-5-[3-(3,4,5-trimethoxyphenyl)but-1-yn-1-yl]pyrimidine-2,4-diamine::JMC517532 Compound 8::Propargyl-linked, 6::Propargyl-substituted antifolate, 8::TMP derivative with propargyl-based linker, 21

SMILES COc1cc(cc(OC)c1OC)C(C)C#Cc1c(C)nc(N)nc1N

InChI Key InChIKey=RUQVXLIOJPKNCM-UHFFFAOYSA-N

Data  1 KI  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 18492   

TargetDihydrofolate reductase(Candida Glabrata)
University of Connecticut

LigandPNGBDBM18492(6-methyl-5-[3-(3,4,5-trimethoxyphenyl)but-1-yn-1-y...)
Affinity DataIC50:  25nMAssay Description:Enzyme activity assay were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over 5 min.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University of Connecticut

LigandPNGBDBM18492(6-methyl-5-[3-(3,4,5-trimethoxyphenyl)but-1-yn-1-y...)
Affinity DataIC50:  1.38E+3nMAssay Description:Enzyme activity assay were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over 5 min.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed