BDBM18525 Bicalutamide::CHEMBL409::N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorobenzene)sulfonyl]-2-hydroxy-2-methylpropanamide::US11046713, Example Bicalutamide::US20230382870, Bicalutumide::US9126941, Bicalutamide::US9682960, CAS

SMILES CC(O)(CS(=O)(=O)c1ccc(F)cc1)C(=O)Nc1ccc(C#N)c(c1)C(F)(F)F

InChI Key InChIKey=LKJPYSCBVHEWIU-UHFFFAOYSA-N

Data  25 KI  70 IC50  7 EC50

PDB links: 10 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 18525   

TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM18525(Bicalutamide | CHEMBL409 | N-[4-cyano-3-(trifluoro...)
Affinity DataKi:  35nMAssay Description:Inhibition of [3H]-DHT binding to T877A androgen receptor of LNCaP cellsMore data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM18525(Bicalutamide | CHEMBL409 | N-[4-cyano-3-(trifluoro...)
Affinity DataKi:  64nMAssay Description:Inhibition of [3H]-DHT binding to androgen receptor of MDA-453 cellsMore data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM18525(Bicalutamide | CHEMBL409 | N-[4-cyano-3-(trifluoro...)
Affinity DataIC50:  400nMAssay Description:Inhibition of T877A androgen receptor of human prostate cancer cells in reporter gene assayMore data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM18525(Bicalutamide | CHEMBL409 | N-[4-cyano-3-(trifluoro...)
Affinity DataIC50:  725nMAssay Description:Inhibition of L701H/T877A mutant androgen receptor of human prostate cancer MDAMB-PCa2b cell proliferationMore data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM18525(Bicalutamide | CHEMBL409 | N-[4-cyano-3-(trifluoro...)
Affinity DataIC50:  173nMAssay Description:Inhibition of human androgen receptor of breast carcinoma MDA-453 cells in reporter gene assayMore data for this Ligand-Target Pair