BDBM18982 1-(1-aminoisoquinolin-7-yl)-3-methyl-N-[4-(2-sulfamoylphenyl)phenyl]-1H-pyrazole-5-carboxamide::SQ-311::pyrazole-based inhibitor, 24a

SMILES Cc1cc(C(=O)Nc2ccc(cc2)-c2ccccc2S(N)(=O)=O)n(n1)-c1ccc2ccnc(N)c2c1

InChI Key InChIKey=AJHNROHOVIQWOE-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 18982   

TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM18982(1-(1-aminoisoquinolin-7-yl)-3-methyl-N-[4-(2-sulfa...)
Affinity DataKi:  0.330nM ΔG°:  -12.8kcal/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were determined ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Bristol-Myers Squibb

LigandPNGBDBM18982(1-(1-aminoisoquinolin-7-yl)-3-methyl-N-[4-(2-sulfa...)
Affinity DataKi:  2.60E+3nM ΔG°:  -7.54kcal/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were determined ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM18982(1-(1-aminoisoquinolin-7-yl)-3-methyl-N-[4-(2-sulfa...)
Affinity DataKi:  6.50E+3nM ΔG°:  -7.00kcal/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were determined ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed