BDBM190326 US10227346, Example 82::US10426135, Example 82::US9670201, 82 3-cyano-2-fluoro-N-(3-((3R,4R)-1-isobutyryl-3-methylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide::US9920054, Example 82

SMILES CC(C)C(=O)N1CC[C@H]([C@@H](C)C1)c1cn(C)c2ncc(NC(=O)c3cccc(C#N)c3F)c(c12)C(F)(F)F

InChI Key InChIKey=JGKBJEOIXCCPRQ-DOTOQJQBSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 190326   

TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM190326(US10227346, Example 82 | US10426135, Example 82 | ...)
Affinity DataIC50:  5.10nMpH: 7.5 T: 2°CAssay Description:Specifically, in one embodiment the aforementioned assay was performed as outlined below. The assay was carried out in black polystyrene, 384-well pl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM190326(US10227346, Example 82 | US10426135, Example 82 | ...)
Affinity DataIC50:  5.10nMAssay Description:The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM190326(US10227346, Example 82 | US10426135, Example 82 | ...)
Affinity DataIC50:  5.10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM190326(US10227346, Example 82 | US10426135, Example 82 | ...)
Affinity DataIC50:  5.10nMAssay Description:The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent