BDBM190575 US9181219, 1-(1,2,3,4-tetrahydroquinolin-1-yl)-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfanyl}ethan-1-one

SMILES FC(F)(F)c1ccc(SCC(=O)N2CCCc3ccccc23)nc1

InChI Key InChIKey=MLUNKIGCWNPKQH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 190575   

TargetTransient receptor potential cation channel subfamily V member 3(Homo sapiens (Human))
Hydra Biosciences

US Patent
LigandPNGBDBM190575(US9181219, 1-(1,2,3,4-tetrahydroquinolin-1-yl)-2-{...)
Affinity DataIC50: <5.00E+3nMAssay Description:Phase 1: TRPV3 cells were induced 20-48 hours, removed from growth plates, and replated at low density (to attain good single-cell physical separatio...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Hydra Biosciences

US Patent
LigandPNGBDBM190575(US9181219, 1-(1,2,3,4-tetrahydroquinolin-1-yl)-2-{...)
Affinity DataIC50: >3.00E+4nMAssay Description:To determine whether compounds were selective for TRPV3 inhibition over inhibition of other ion channel types, the human ERG (hERG), NaV1.2, and TRPV...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily V member 3(Homo sapiens (Human))
Hydra Biosciences

US Patent
LigandPNGBDBM190575(US9181219, 1-(1,2,3,4-tetrahydroquinolin-1-yl)-2-{...)
Affinity DataIC50: <1.00E+3nMAssay Description:To determine whether compounds were selective for TRPV3 inhibition over inhibition of other ion channel types, the human ERG (hERG), NaV1.2, and TRPV...More data for this Ligand-Target Pair
In DepthDetails US Patent