BDBM192753 Hesperadin::US10981896, Compound Hesperadin
SMILES CCS(=O)(=O)Nc1ccc2NC(=O)\C(=C(/Nc3ccc(CN4CCCCC4)cc3)c3ccccc3)c2c1
InChI Key InChIKey=GLDSKRNGVVYJAB-DQSJHHFOSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 192753
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
Board of Regents, The University of Texas System
US Patent
Board of Regents, The University of Texas System
US Patent
Affinity DataIC50: 225nMAssay Description:MELK and its substrate, Bcl-G were both recombinantly expressed and purified for use in screening assays (See Methods). 752 compounds from an in-hous...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1 [547-977](Homo sapiens (Human))
University of Washington
University of Washington
Affinity DataIC50: 780nMpH: 7.5Assay Description:Inhibitors (initial concentration 10 or 60 μM, three-fold serial dilutions) were incubated with IRE1α* in cleavage buffer (20 mM HEPES at p...More data for this Ligand-Target Pair