BDBM195064 US9212153, 118,Ex. 84

SMILES COC1CCC2(Cc3ccc(OCC(F)(F)F)cc3C22CN(C)C(N)=N2)CC1

InChI Key InChIKey=PWSOESGNVPAJGB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 195064   

TargetBeta-secretase 1 [1-458](Homo sapiens (Human))
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM195064(US9212153, 118,Ex. 84)
Affinity DataIC50:  9nMpH: 4.5 T: 2°CAssay Description:Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity using commercially available substrate HiLyte Fluor 488...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent