BDBM19651 (2R)-2-(cyclopentylmethyl)-4-(morpholin-4-yl)-4-oxo-N-[(2S)-1-{[4-(trifluoromethoxy)phenyl]amino}propan-2-yl]butanamide::succinamide peptidomimetic, 17

SMILES C[C@@H](CNc1ccc(OC(F)(F)F)cc1)NC(=O)[C@H](CC1CCCC1)CC(=O)N1CCOCC1

InChI Key InChIKey=ISASYAAYECPXSH-PKOBYXMFSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 19651   

TargetCathepsin S(Homo sapiens (Human))
Gnf

LigandPNGBDBM19651((2R)-2-(cyclopentylmethyl)-4-(morpholin-4-yl)-4-ox...)
Affinity DataKi:  31nM ΔG°:  -10.6kcal/molepH: 5.5 T: 2°CAssay Description:The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Gnf

LigandPNGBDBM19651((2R)-2-(cyclopentylmethyl)-4-(morpholin-4-yl)-4-ox...)
Affinity DataKi:  3.71E+3nMAssay Description:The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Gnf

LigandPNGBDBM19651((2R)-2-(cyclopentylmethyl)-4-(morpholin-4-yl)-4-ox...)
Affinity DataKi: >3.00E+4nMAssay Description:The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed