BDBM199095 US9221839, 3a
SMILES COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@@]12COC[C@@H]1S(=O)(=O)N(C)C(=N)N2
InChI Key InChIKey=DKOVCLRDSGGWRB-LPHOPBHVSA-N
Data 2 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 199095
Affinity DataKi: 476nM ΔG°: -8.76kcal/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 are determined in a
time-resolved endpoint proteolysis assay that measures hydrolysis of the
QSY7-EISE...More data for this Ligand-Target Pair
Affinity DataKi: 872nM ΔG°: -8.40kcal/molepH: 5.0 T: 2°CAssay Description:A homogeneous time-resolved FRET assay can be used to determine IC50
values for inhibitors of the soluble human BACE1 catalytic domain. This
assay ...More data for this Ligand-Target Pair