BDBM199103 US9221839, 5a
SMILES CN1C(=N)N[C@@]2(COC[C@@H]2S1(=O)=O)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F
InChI Key InChIKey=UMTXXAYFIKSALN-YJBOKZPZSA-N
Data 2 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 199103
Affinity DataKi: 55.2nM ΔG°: -10.1kcal/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 are determined in a
time-resolved endpoint proteolysis assay that measures hydrolysis of the
QSY7-EISE...More data for this Ligand-Target Pair
Affinity DataKi: 197nM ΔG°: -9.29kcal/molepH: 5.0 T: 2°CAssay Description:A homogeneous time-resolved FRET assay can be used to determine IC50
values for inhibitors of the soluble human BACE1 catalytic domain. This
assay ...More data for this Ligand-Target Pair