BDBM199109 US9221839, 6b
SMILES CN1C(=N)N[C@]2(COC[C@H]2S1(=O)=O)c1cc(NC(=O)c2cnc(cn2)C(F)F)ccc1F
InChI Key InChIKey=IQUBPELHSBAKON-RDTXWAMCSA-N
Data 2 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 199109
Affinity DataKi: 17.4nM ΔG°: -10.8kcal/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 are determined in a
time-resolved endpoint proteolysis assay that measures hydrolysis of the
QSY7-EISE...More data for this Ligand-Target Pair
Affinity DataKi: 27.2nM ΔG°: -10.5kcal/molepH: 5.0 T: 2°CAssay Description:A homogeneous time-resolved FRET assay can be used to determine IC50
values for inhibitors of the soluble human BACE1 catalytic domain. This
assay ...More data for this Ligand-Target Pair