BDBM199115 US9221839, 6e
SMILES COc1cnc(C(=O)Nc2ccc(F)c(c2)[C@]23COC[C@H]2S(=O)(=O)N(C)C(=N)N3)c(F)c1
InChI Key InChIKey=LEHXYLCBOVXRTG-DNVCBOLYSA-N
Data 2 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 199115
Affinity DataKi: 6.90nM ΔG°: -11.3kcal/molepH: 5.0 T: 2°CAssay Description:Inhibitor IC50s at purified human autoBACE-2 are determined in a
time-resolved endpoint proteolysis assay that measures hydrolysis of the
QSY7-EISE...More data for this Ligand-Target Pair
Affinity DataKi: 15.8nM ΔG°: -10.8kcal/molepH: 5.0 T: 2°CAssay Description:A homogeneous time-resolved FRET assay can be used to determine IC50
values for inhibitors of the soluble human BACE1 catalytic domain. This
assay ...More data for this Ligand-Target Pair